绝经后女性5-羟色胺转运体（5-HTT）与单胺氧化酶（MAO）基因多态性、情绪及焦虑水平之间关系的评估
Evaluation of the relationship between 5-HTT and MAO gene polymorphisms, mood and level of anxiety among postmenopausal women.
作者信息
Grochans Elżbieta, Jurczak Anna, Szkup Małgorzata, Samochowiec Agnieszka, Włoszczak-Szubzda Anna, Karakiewicz Beata, Grzywacz Anna, Brodowska Agnieszka, Samochowiec Jerzy
机构信息
Department of Nursing, Pomeranian Medical University in Szczecin, 48 Żołnierska St., 71-210 Szczecin, Poland.
Department of Clinical Psychology, Institute of Psychology, University of Szczecin, 69 Krakowska St., 71-017 Szczecin, Poland.
出版信息
Int J Environ Res Public Health. 2014 Dec 24;12(1):268-81. doi: 10.3390/ijerph120100268.
OBJECTIVE
The aim of this study was to analyze how mood and anxiety level are related to the functional genetic polymorphism in the promoter region of SLC6A4 (5-HTTLPR) and the 30-bp VNTR polymorphism in the MAO A promoter region.
METHODS
The study involved 272 postmenopausal women from Poland. The authors employed the State-Trait Anxiety Inventory for measuring levels of anxiety, the Mood Adjective Check List for measuring mood, and genetic tests.
RESULTS
Analysis did not show any statistically significant differences in the mean levels of anxiety, and mood disorders in women in relation to genotypes of the 5-HTTLPR (SLC6A4) polymorphism and the 30-bp VNTR polymorphism in the MAO A promoter region. However, these problems were more severe among women with s/s genotype. In the case of MAO A gene polymorphism, the level of anxiety was higher in women with a 4/4 genotype.
CONCLUSIONS
The study did not prove the possibility of the identification of homogeneous groups of women with an elevated risk of developing anxiety and mood disorders during the post-menopausal period. Nevertheless, it showed that respondents with s/s genotype of the 44-bp polymorphism in the 5-HTT (SLC6A4) promoter region had the highest average anxiety levels both as a state and as a trait. Furthermore, the analysis of the 30-bp VNTR polymorphism in the MAO A promoter region demonstrated slight differences in anxiety levels between the women, indicating that those with a 4/4 genotype had higher severity of anxiety symptoms.
目的
本研究旨在分析情绪和焦虑水平如何与SLC6A4（5-羟色胺转运体相关蛋白基因启动子区）启动子区域的功能基因多态性以及单胺氧化酶A（MAO A）启动子区域的30个碱基对可变数目串联重复序列（VNTR）多态性相关。
方法
该研究纳入了272名来自波兰的绝经后女性。作者采用状态-特质焦虑量表测量焦虑水平，用情绪形容词检查表测量情绪，并进行基因检测。
结果
分析显示，绝经后女性的焦虑平均水平和情绪障碍与5-羟色胺转运体相关蛋白基因启动子区（SLC6A4）多态性的基因型以及MAO A启动子区域的30个碱基对VNTR多态性之间，不存在任何统计学上的显著差异。然而，s/s基因型的女性中这些问题更为严重。就MAO A基因多态性而言，4/4基因型的女性焦虑水平更高。
结论
该研究未证实识别出绝经后期发生焦虑和情绪障碍风险升高的同质女性群体的可能性。尽管如此，研究表明，5-羟色胺转运体（SLC6A4）启动子区域44个碱基对多态性的s/s基因型应答者，无论作为一种状态还是特质，平均焦虑水平最高。此外，对MAO A启动子区域30个碱基对VNTR多态性的分析表明，女性之间在焦虑水平上存在细微差异，表明4/4基因型的女性焦虑症状更严重。
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