Ramesh Aramandla, Kumar Anil, Aramandla Mounika P, Nyanda Alfred M
Department of Biochemistry & Cancer Biology, Meharry Medical College, 1005 D.B. Todd Blvd., Nashville, TN 37208, USA.
Department of Neuroscience & Pharmacology, Meharry Medical College, 1005 D.B. Todd Blvd., Nashville, TN 37208, USA.
Int J Environ Res Public Health. 2014 Dec 25;12(1):322-34. doi: 10.3390/ijerph120100322.
This study reports the concentrations of polycyclic aromatic hydrocarbons (PAHs) in human blood sera samples (n = 650) obtained at autopsy from individuals who died of drug abuse, alcohol toxicity, homicide, suicide and other unknown causes. The analyzed samples from decedents revealed the presence of PAHs of which B(a)P was the most predominant one, followed by benzo(b)fluoranthene and benzo(k)fluoranthene. The other PAHs detected sporadically and measured were benzo(g,h,i)perylene, acenaphthene, anthracene, phenanthrene, and fluoranthene The mean concentrations of PAHs were greater in the twenties to fifties age groups compared to others. The PAH residue levels detected were high in African Americans compared to Caucasians, Asians, and Hispanics. It appears that environmental exposure, dietary intake and in some cases occupational exposure may have contributed to the PAH body burden. While the PAH residue concentrations measured fall within the range of those reported for healthy adults elsewhere, in isolated cases, the concentrations detected were high, calling the need for a reduction in PAH emissions and human biomonitoring studies for purposes of risk assessment.
本研究报告了从死于药物滥用、酒精中毒、他杀、自杀及其他不明原因的个体尸检时获取的人体血清样本（n = 650）中多环芳烃（PAHs）的浓度。对死者样本的分析显示存在多环芳烃，其中苯并(a)芘最为主要，其次是苯并(b)荧蒽和苯并(k)荧蒽。偶尔检测并测定的其他多环芳烃有苯并(g,h,i)苝、苊、蒽、菲和荧蒽。与其他年龄段相比，二十多岁到五十多岁年龄组的多环芳烃平均浓度更高。与白种人、亚洲人和西班牙裔相比，非裔美国人检测到的多环芳烃残留水平较高。看来环境暴露、饮食摄入以及在某些情况下的职业暴露可能导致了人体多环芳烃负担。虽然所测的多环芳烃残留浓度在其他地方报道的健康成年人浓度范围内，但在个别情况下，检测到的浓度较高，这表明需要减少多环芳烃排放并开展人体生物监测研究以进行风险评估。
