Makinson Christopher D, Huguenard John R
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.
Nat Neurosci. 2015 Jan;18(1):2-4. doi: 10.1038/nn.3902.
Loss of the receptor tyrosine kinase ErbB4 in somatostatin (SOM) inhibitory neurons of the thalamic reticular nucleus (TRN) enhances top-down cortical feedback, improving feature detection at the cost of reduced ability to switch attention. The study furthers our understanding of the circuit mechanisms underlying TRN function.
丘脑网状核(TRN)中生长抑素(SOM)抑制性神经元的受体酪氨酸激酶ErbB4缺失会增强自上而下的皮质反馈,以降低注意力切换能力为代价改善特征检测。这项研究进一步加深了我们对TRN功能背后的神经回路机制的理解。