Nakajima Satoshi, Okada Tomohisa, Yamamoto Akira, Kanagaki Mitsunori, Fushimi Yasutaka, Okada Tsutomu, Arakawa Yoshiki, Takagi Yasushi, Miyamoto Susumu, Togashi Kaori
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8507 Japan.
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8507 Japan.
Clin Imaging. 2015 May-Jun;39(3):390-5. doi: 10.1016/j.clinimag.2014.12.002. Epub 2014 Dec 12.
The objective was to evaluate diagnostic performance of dynamic susceptibility-contrast perfusion-weighted imaging, diffusion-weighted imaging, and (18)F-fluorodeoxyglucose positron emission tomography in differentiating primary central nervous system lymphoma (PCNSL) and glioblastoma.
Twenty-three glioblastomas and 11 PCNSLs were analyzed with uncorrected cerebral blood volume (CBV) ratio, fifth percentile value of cumulative apparent diffusion coefficient histogram (ADC5%), and maximum standardized uptake value (SUVmax) using regions of interest created semiautomatically on enhancing areas.
Uncorrected CBV ratio was highly capable of differentiating PCNSL from glioblastoma, as well as SUVmax and ADC5%.
Uncorrected CBV ratio demonstrates high diagnostic performance comparable to SUVmax.
评估动态磁敏感对比灌注加权成像、弥散加权成像和（18）F-氟脱氧葡萄糖正电子发射断层扫描在鉴别原发性中枢神经系统淋巴瘤（PCNSL）和胶质母细胞瘤中的诊断性能。
对23例胶质母细胞瘤和11例PCNSL进行分析，使用在强化区域半自动创建的感兴趣区，计算未校正脑血容量（CBV）比值、累积表观扩散系数直方图的第5百分位数（ADC5%）和最大标准化摄取值（SUVmax）。
未校正CBV比值以及SUVmax和ADC5%在鉴别PCNSL和胶质母细胞瘤方面具有很高的能力。
未校正CBV比值显示出与SUVmax相当的高诊断性能。
