Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Freiburg, Germany.
Psychother Psychosom. 2015;84(1):51-6. doi: 10.1159/000369586. Epub 2014 Dec 24.
The Cognitive Behavioral Analysis System of Psychotherapy (CBASP), initially developed as an outpatient treatment for chronic depression (CD), has been adapted as a multidisciplinary 12-week inpatient program for CD.
Seventy inpatients with CD and treatment resistance were included in a noncontrolled trial. The Hamilton Depression Rating Scale served as the primary outcome measure. Prospective naturalistic follow-up assessments were conducted 6 and 12 months after discharge.
Dropout rate was 7.1%; 90.4% perceived the program as helpful. Pre-post comparisons yielded strong effect sizes; 75.7% of the intention-to-treat sample responded, and 40.0% remitted. Nonremission was associated with experiencing temporary deterioration of symptoms during treatment. After 6 months 75.0% and after 12 months 48.0% of patients sustained response.
The CBASP program appears as a feasible acute treatment for treatment-resistant CD inpatients with promising outcome. However, the continuation of treatment after discharge should be optimized especially for patients with subjective deterioration during treatment.
认知行为分析系统疗法（CBASP）最初是作为慢性抑郁症（CD）的门诊治疗方法开发的，现已被改编为多学科的 12 周 CD 住院治疗方案。
70 名患有 CD 和治疗抵抗的住院患者参与了一项非对照试验。汉密尔顿抑郁评定量表作为主要的结果衡量标准。在出院后 6 个月和 12 个月进行前瞻性自然随访评估。
脱落率为 7.1%；90.4%的患者认为该方案有帮助。治疗前后的比较显示出较强的效果量；意向治疗样本中有 75.7%的患者有反应，40.0%的患者缓解。未缓解与治疗过程中症状的暂时恶化有关。在 6 个月时有 75.0%的患者和在 12 个月时有 48.0%的患者保持了缓解。
CBASP 方案似乎是一种可行的治疗 CD 住院患者的急性治疗方法，具有良好的预后。然而，应该优化出院后的治疗延续，特别是对于治疗过程中主观恶化的患者。
