Huang Xiang-Lei
Department of Nuclear Medicine, Xuzhou Central Hospital, 199# Liberation Road S. Road, Xuzhou, 221009, China.
Cell Biochem Biophys. 2015 Jun;72(2):359-61. doi: 10.1007/s12013-014-0464-9.
To evaluate the serum levels of adipocyte fatty acid-binding protein (A-FABP) and high-sensitivity C reactive protein (hs-CRP) in patients with acute ischemic stroke (AIS), and correlations among A-FABP, hs-CRP, and AIS, 108 patients with AIS and 86 healthy controls were examined. The levels of hs-CRP and A-FABP were detected by ELISAs. The stroke severity was determined using the modified Rankin scale (mRS). Patients with AIS were divided into those with mild (mRS ≤ 3) and severe disease (mRS > 3). Regression analysis was performed to test association between hs-CRP and A-FABP. Serum levels of hs-CRP and A-FABP were significantly higher in patients with AIS compared with healthy controls. Furthermore, more severe AIS was associated with higher levels of these markers. Regression analysis demonstrated a weak but significant association between A-FABP and hs-CRP. A-FABP and hs-CRP are associated with AIS, and may be involved in the pathogenesis of AIS.
为评估急性缺血性脑卒中（AIS）患者血清中脂肪细胞脂肪酸结合蛋白（A-FABP）和高敏C反应蛋白（hs-CRP）的水平，以及A-FABP、hs-CRP与AIS之间的相关性，对108例AIS患者和86例健康对照者进行了检测。采用酶联免疫吸附测定法（ELISA）检测hs-CRP和A-FABP水平。使用改良Rankin量表（mRS）确定卒中严重程度。AIS患者被分为轻度（mRS≤3）和重度（mRS>3）疾病患者。进行回归分析以检验hs-CRP与A-FABP之间的关联。与健康对照者相比，AIS患者血清hs-CRP和A-FABP水平显著更高。此外，更严重的AIS与这些标志物的更高水平相关。回归分析表明A-FABP与hs-CRP之间存在微弱但显著的关联。A-FABP和hs-CRP与AIS相关，可能参与了AIS的发病机制。
