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经弓形虫裂解物抗原处理后，无胸腺裸鼠体内白细胞介素-12显著产生且肿瘤缩小。

Prominent IL-12 production and tumor reduction in athymic nude mice after Toxoplasma gondii lysate antigen treatment.

作者信息

Pyo Kyoung-Ho, Jung Bong-Kwang, Xin Chun-Feng, Lee You-Won, Chai Jong-Yil, Shin Eun-Hee

机构信息

Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110-799, Korea.

Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110-799, Korea. ; Seoul National University Bundang Hospital, Seongnam 463-707, Korea.

出版信息

Korean J Parasitol. 2014 Dec;52(6):605-12. doi: 10.3347/kjp.2014.52.6.605. Epub 2014 Dec 23.

DOI:10.3347/kjp.2014.52.6.605
PMID:25548411
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4277022/
Abstract

Toxoplasma gondii is an intracellular protozoan parasite that causes a Th1 cellular immunity. Our previous study showed that T. gondii lysate antigen (TLA) treatment in S180 tumor-bearing mice resulted in tumor reduction by suppressing CD31 expression, a marker of angiogenesis. In the present study, to investigate tumor suppressive effect of TLA under the absence of T lymphocytes, athymic nude mice were compared with euthymic mice in the anti-tumorigenic effect triggered by TLA in CT26 tumors. According to the results, intratumorally injected TLA reduced tumor growth and TIMP-1 level, a metastatic marker, in both euthymic and athymic mice. TLA treatment led to a sharp increase in IL-12 expression in serum cytokine profiling of athymic mice, and increased MyD88 signals in macrophages derived from the bone marrow, implying the activation of innate immunity. The selective induction of IL-12 by TLA treatment had an anti-tumorigenic effect.

摘要

弓形虫是一种引起Th1细胞免疫的细胞内原生动物寄生虫。我们之前的研究表明，在荷S180肿瘤小鼠中，弓形虫裂解物抗原（TLA）治疗通过抑制作为血管生成标志物的CD31表达来使肿瘤缩小。在本研究中，为了研究在无T淋巴细胞情况下TLA的肿瘤抑制作用，将无胸腺裸鼠与正常胸腺小鼠在TLA触发的CT26肿瘤抗肿瘤作用方面进行了比较。根据结果，瘤内注射TLA可降低正常胸腺小鼠和无胸腺小鼠的肿瘤生长以及转移标志物TIMP-1水平。TLA治疗导致无胸腺小鼠血清细胞因子谱中IL-12表达急剧增加，并增加了源自骨髓的巨噬细胞中的MyD88信号，这意味着先天免疫被激活。TLA治疗对IL-12的选择性诱导具有抗肿瘤作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5175/4277022/61d7c80e5999/kjp-52-605-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5175/4277022/b33128a44cf9/kjp-52-605-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5175/4277022/c21cb1c714e0/kjp-52-605-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5175/4277022/9823ece7ef50/kjp-52-605-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5175/4277022/61d7c80e5999/kjp-52-605-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5175/4277022/b33128a44cf9/kjp-52-605-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5175/4277022/c21cb1c714e0/kjp-52-605-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5175/4277022/9823ece7ef50/kjp-52-605-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5175/4277022/61d7c80e5999/kjp-52-605-g004.jpg

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