Jain Pooja, Mohapatra Sradhanjali, Farooq Uzma, Hassan Nazia, Mirza Mohd Aamir, Iqbal Zeenat
Department of Pharmaceutics, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi, 110030, India.
Curr Cancer Drug Targets. 2025;25(1):38-48. doi: 10.2174/0115680096282503240124104029.
It is a well-known fact that cancer is considered the second leading cause of mortality across the globe. Although the human oral cavity and intestine are the natural habitat of thousands of microbes, dysbiosis results in malignancies, such as oral squamous cell carcinoma and colorectal cancer. Amongst the intestinal microbes, is a deadly carcinogen. Also, causative pathogens for the development of pancreatic and colorectal cancer are found in the oral cavity, such as and . Many periodontopathic micro- organisms, like sp., Peptostreptococcus sp., Prevotella sp., Fusobacterium sp., Porphyromonas gingivalis, and Capnocytophaga gingivalis, strongly have an impact on the development of oral cancers. Three basic mechanisms are involved in pathogen-mediated cancer development, like chronic inflammation-mediated angiogenesis, inhibition of cellular apoptosis, and release of carcinogenic by-products. Microbiota has a dichotomous role to play in cancer, i.e., microbiota can be used for cancer management too. Shreds of evidence are there to support the fact that microbiota enhances the chemotherapeutic drug efficacy. This review presents the possible mechanism of the oncogenic effect of microbiota with emphasis on the oral microbiome and also attempts to explain the intricate role of microbiota in cancer management.
众所周知，癌症被认为是全球第二大致死原因。尽管人类口腔和肠道是数千种微生物的天然栖息地，但生态失调会导致恶性肿瘤，如口腔鳞状细胞癌和结直肠癌。在肠道微生物中， 是一种致命的致癌物。此外，在口腔中也发现了导致胰腺癌和结直肠癌发生的致病病原体，如 和 。许多牙周病原微生物，如 菌属、消化链球菌属、普雷沃菌属、梭杆菌属、牙龈卟啉单胞菌和牙龈二氧化碳嗜纤维菌，对口腔癌的发生有强烈影响。病原体介导的癌症发展涉及三种基本机制，如慢性炎症介导的血管生成、细胞凋亡的抑制以及致癌副产物的释放。微生物群在癌症中起着双重作用，即微生物群也可用于癌症治疗。有证据支持微生物群可提高化疗药物疗效这一事实。本综述阐述了微生物群致癌作用的可能机制，重点是口腔微生物群，并试图解释微生物群在癌症治疗中的复杂作用。
