Suzuki Kazuyoshi, Tamano Masaya, Katayama Yasumi, Kuniyoshi Toru, Kagawa Kagemasa, Takada Hiroshi, Suzuki Kazutomo
Kazuyoshi Suzuki, Masaya Tamano, Yasumi Katayama, Toru Kuniyoshi, Kagemasa Kagawa, Hiroshi Takada, Kazutomo Suzuki, Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital, Saitama 343-8555, Japan.
World J Gastroenterol. 2014 Dec 21;20(47):17877-82. doi: 10.3748/wjg.v20.i47.17877.
To investigate the occurrence and severity of pruritus in chronic hepatitis C patients treated with or without interferon (IFN) therapy.
A total of 89 patients with chronic hepatitis C and 55 control (non-hepatitis) patients were asked to rate their experience of diurnal and nocturnal pruritus in the preceding week using a visual analogue scale (VAS) and a five-point scale, respectively. Blood samples were taken and serum thymus and activation-regulated chemokine (TARC) levels were measured by enzyme-linked immunosorbent assay.
A significantly greater proportion of chronic hepatitis C patients experienced nocturnal pruritus compared with control (58.4% vs 5.5%, P < 0.0001). Chronic hepatitis C patients also had more severe pruritus compared with control patients, indicated by the higher mean VAS scores in both the IFN-treated and non-IFN-treated groups. In particular, patients who received combined peginterferon alfa-2b and ribavirin had significantly higher mean VAS scores than those receiving peginterferon alfa-2a or no IFN treatment. Serum TARC levels did not correlate with pruritus scores, and no significant differences in TARC levels were observed between the IFN-treated and non-IFN-treated groups.
Patients with chronic hepatitis C experience pruritus more than those without. Serum TARC levels do not correlate with pruritus severity in chronic hepatitis C patients.
研究接受或未接受干扰素（IFN）治疗的慢性丙型肝炎患者瘙痒的发生情况及严重程度。
共89例慢性丙型肝炎患者和55例对照（非肝炎）患者，分别使用视觉模拟量表（VAS）和五点量表对他们前一周白天和夜间的瘙痒体验进行评分。采集血样，采用酶联免疫吸附测定法检测血清胸腺和活化调节趋化因子（TARC）水平。
与对照组相比，慢性丙型肝炎患者夜间瘙痒的比例显著更高（58.4%对5.5%，P<0.0001）。慢性丙型肝炎患者的瘙痒也比对照患者更严重，这在干扰素治疗组和未接受干扰素治疗组中平均VAS评分更高得到体现。特别是，接受聚乙二醇干扰素α-2b和利巴韦林联合治疗的患者平均VAS评分显著高于接受聚乙二醇干扰素α-2a或未接受干扰素治疗的患者。血清TARC水平与瘙痒评分无关，在干扰素治疗组和未接受干扰素治疗组之间未观察到TARC水平的显著差异。
慢性丙型肝炎患者比无该病的患者更容易出现瘙痒。血清TARC水平与慢性丙型肝炎患者的瘙痒严重程度无关。
