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劳氏肉瘤病毒长末端重复序列增强子对猴空泡病毒40（SV40）DNA复制的抑制作用

Inhibition of SV40 DNA replication by Rous sarcoma virus LTR enhancer.

作者信息

Binninger D, Ferdinand F J, Rübsamen-Waigmann H

机构信息

Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, Frankfurt/Main, Federal Republic of Germany.

出版信息

Arch Virol. 1989;107(3-4):291-9. doi: 10.1007/BF01317924.

DOI:10.1007/BF01317924
PMID:2554858
Abstract

Simian virus 40 (SV40) late region recombinant constructs containing the Rous sarcoma virus (RSV) src gene along with RSV enhancer stimulated expression but completely abolished SV40 DNA replication. Constructs, in which the heterologous enhancer sequences were omitted, did replicate normally in African green monkey kidney cells and, in the presence of helper virus, gave rise to infectious progeny. Inhibition of SV40 DNA replication follows a cis-acting mechanism and is most likely due to a conformational change of the SV40 chromatin structure.

摘要

含有劳斯肉瘤病毒（RSV）src基因以及RSV增强子的猿猴病毒40（SV40）晚期区域重组构建体刺激了表达，但完全消除了SV40 DNA复制。省略了异源增强子序列的构建体在非洲绿猴肾细胞中正常复制，并且在辅助病毒存在的情况下产生有感染性的后代。SV40 DNA复制的抑制遵循顺式作用机制，很可能是由于SV40染色质结构的构象变化。

相似文献

1
Inhibition of SV40 DNA replication by Rous sarcoma virus LTR enhancer.劳氏肉瘤病毒长末端重复序列增强子对猴空泡病毒40（SV40）DNA复制的抑制作用
Arch Virol. 1989;107(3-4):291-9. doi: 10.1007/BF01317924.
2
Enhancer activity correlates with the oncogenic potential of avian retroviruses.增强子活性与禽逆转录病毒的致癌潜力相关。
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3
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Cloning of Rous sarcoma virus enhancer factor genes. II. RSV-EF-II, abundantly expressed in fibroblasts and muscle tissue, binds to an octamer sequence, 5'-GTACCACC-3', in the noncoding strand of RSV enhancer.劳氏肉瘤病毒增强子因子基因的克隆。II. RSV-EF-II在成纤维细胞和肌肉组织中大量表达，与劳氏肉瘤病毒增强子非编码链上的八聚体序列5'-GTACCACC-3'结合。
Virology. 1996 Aug 1;222(1):133-43. doi: 10.1006/viro.1996.0404.
5
Cloning of Rous sarcoma virus enhancer factor genes. I. Evidence that RSV-EF-I is related to Y-box (inverted CCAAT) binding proteins and binds to multiple motifs in the RSV enhancer.劳氏肉瘤病毒增强子因子基因的克隆。I. 证据表明劳氏肉瘤病毒增强子因子-1与Y盒（反向CCAAT）结合蛋白相关，并与劳氏肉瘤病毒增强子中的多个基序结合。
Virology. 1994 Feb;198(2):514-23. doi: 10.1006/viro.1994.1062.
6
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Nucleic Acids Res. 1987 Dec 10;15(23):9841-59. doi: 10.1093/nar/15.23.9841.
7
Effects of position and orientation of the 72-base-pair-repeat transcriptional enhancer on replication from the simian virus 40 core origin.72碱基对重复转录增强子的位置和方向对猿猴病毒40核心起点复制的影响。
J Virol. 1987 Oct;61(10):2973-80. doi: 10.1128/JVI.61.10.2973-2980.1987.
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trans-activation of viral enhancers by the hepatitis B virus X protein.乙型肝炎病毒X蛋白对病毒增强子的反式激活作用。
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引用本文的文献

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Interference of the simian virus 40 origin of replication by the cytomegalovirus immediate early gene enhancer: evidence for competition of active regulatory chromatin conformation in a single domain.巨细胞病毒立即早期基因增强子对猿猴病毒40复制起点的干扰：单一结构域中活性调控染色质构象竞争的证据
Mol Cell Biol. 2000 Jun;20(11):4062-74. doi: 10.1128/MCB.20.11.4062-4074.2000.
2
Mutational analysis of the simian immunodeficiency virus SIVmac nef gene.猴免疫缺陷病毒SIVmac nef基因的突变分析
J Virol. 1991 Oct;65(10):5237-43. doi: 10.1128/JVI.65.10.5237-5243.1991.

本文引用的文献

1
An SV40 "enhancer trap" incorporates exogenous enhancers or generates enhancers from its own sequences.一个SV40“增强子陷阱”包含外源性增强子或从其自身序列产生增强子。
Cell. 1984 Apr;36(4):983-92. doi: 10.1016/0092-8674(84)90048-5.
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Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA.逆转录病毒和SV40序列在DNA显微注射后增强生化转化的位置及功能。
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Enhancer elements.增强子元件
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Molecular cloning and characterization of avian sarcoma virus circular DNA molecules.禽肉瘤病毒环状DNA分子的分子克隆与特性分析
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Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product.禽肉瘤病毒癌基因（src）的核苷酸序列及基因产物的推测氨基酸序列。
Nature. 1980 Sep 18;287(5779):198-203. doi: 10.1038/287198a0.
8
The expression of pp60src and its associated protein kinase activity in cells infected with different transformation-defective temperature-sensitive mutants of Rous sarcoma virus.劳氏肉瘤病毒不同转化缺陷型温度敏感突变体感染的细胞中pp60src的表达及其相关蛋白激酶活性
Virology. 1980 Apr 30;102(2):453-7. doi: 10.1016/0042-6822(80)90113-0.
9
Multiple enhancer domains in the 3' terminus of the Prague strain of Rous sarcoma virus.劳氏肉瘤病毒布拉格株3'末端的多个增强子结构域。
Nucleic Acids Res. 1984 Aug 24;12(16):6427-42. doi: 10.1093/nar/12.16.6427.
10
Assembly of transfected DNA into chromatin: structural changes in the origin-promoter-enhancer region upon replication.转染的DNA组装入染色质：复制时起始子-启动子-增强子区域的结构变化
EMBO J. 1984 Jun;3(6):1243-53. doi: 10.1002/j.1460-2075.1984.tb01959.x.