El-Sakhawy Mohamed, Kamel Samir, Salama Ahmed, Sarhan Hebat-Allah
Cellulose and Paper Department, National Research Center, Dokki, Cairo 12622, Egypt.
J Drug Deliv. 2014;2014:575969. doi: 10.1155/2014/575969. Epub 2014 Dec 4.
Carboxymethyl cellulose acetate butyrate (CMCAB) has gained increasing importance in several fields, particularly in coating technologies and pharmaceutical research. CMCAB is synthesized by esterification of CMC sodium salt with acetic and butyric anhydrides. CMCAB mixed esters are relatively high molecular weight (MW) thermoplastic polymers with high glass transition temperatures (Tg). CMCAB ester is dispersible in water and soluble in a wide range of organic solvents, allowing varied opportunity to the solvent choice. It makes application of coatings more consistent and defect-free. Its ability to slow down the release rate of highly water-soluble compounds and to increase the dissolution of poorly soluble compounds makes CMCAB a unique and potentially valuable tool in pharmaceutical and amorphous solid dispersions (ASD) formulations.
羧甲基纤维素乙酸丁酸酯（CMCAB）在多个领域正变得越来越重要，尤其是在涂层技术和药物研究领域。CMCAB是通过羧甲基纤维素钠盐与乙酸酐和丁酸酐的酯化反应合成的。CMCAB混合酯是具有较高玻璃化转变温度（Tg）的相对高分子量（MW）热塑性聚合物。CMCAB酯可分散于水中，并可溶于多种有机溶剂，这为溶剂选择提供了多种机会。它使涂层的应用更加均匀且无缺陷。其减缓高水溶性化合物释放速率以及增加难溶性化合物溶解的能力，使得CMCAB成为药物和无定形固体分散体（ASD）制剂中一种独特且具有潜在价值的工具。
