Department of Industrial and Physical Pharmacy , Purdue University , West Lafayette , Indiana 47907 , United States.
Ashland Specialty Ingredients , 500 Hercules Road , Wilmington , Delaware 19808 , United States.
Biomacromolecules. 2018 Jul 9;19(7):2351-2376. doi: 10.1021/acs.biomac.8b00517. Epub 2018 Jun 22.
Cellulose ethers have proven to be highly useful natural-based polymers, finding application in areas including food, personal care products, oil field chemicals, construction, paper, adhesives, and textiles. They have particular value in pharmaceutical applications due to characteristics including high glass transition temperatures, high chemical and photochemical stability, solubility, limited crystallinity, hydrogen bonding capability, and low toxicity. With regard to toxicity, cellulose ethers have essentially no ability to permeate through gastrointestinal enterocytes and many are already in formulations approved by the U.S. Food and Drug Administration. We review pharmaceutical applications of these valuable polymers from a structure-property-function perspective, discussing each important commercial cellulose ether class; carboxymethyl cellulose, methyl cellulose, hydroxypropylcellulose, hydroxypropyl methyl cellulose, and ethyl cellulose, and cellulose ether esters including hydroxypropyl methyl cellulose acetate succinate and carboxymethyl cellulose acetate butyrate. We also summarize their syntheses, basic material properties, and key pharmaceutical applications.
纤维素醚已被证明是非常有用的天然基聚合物，在食品、个人护理产品、油田化学品、建筑、造纸、胶粘剂和纺织品等领域都有应用。由于具有高玻璃化转变温度、高化学和光化学稳定性、溶解性、有限的结晶度、氢键能力和低毒性等特点，它们在制药应用中具有特殊的价值。关于毒性，纤维素醚基本上没有穿透胃肠道肠细胞的能力，而且许多已经在获得美国食品和药物管理局批准的配方中使用。我们从结构-性质-功能的角度回顾了这些有价值的聚合物在制药方面的应用，讨论了每一种重要的商业纤维素醚类别：羧甲基纤维素、甲基纤维素、羟丙基纤维素、羟丙基甲基纤维素和乙基纤维素，以及纤维素醚酯，包括羟丙基甲基纤维素醋酸琥珀酸酯和醋酸丁酸纤维素。我们还总结了它们的合成、基本材料性质和关键的制药应用。
