Nayyar Megha, Imagawa David K, Tirkes Temel, Demirjian Aram N, Houshyar Roozbeh, Sandrasegaran Kumar, Nangia Chaitali S, Seery Tara, Bhargava P, Choi Joon Ii, Lall Chandana
Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
University of California, Irvine, Orange, CA, USA.
Clin Mol Hepatol. 2014 Dec;20(4):406-10. doi: 10.3350/cmh.2014.20.4.406.
Bi-phenotypic neoplasm refers to tumors derived from a common cancer stem cell with unique capability to differentiate histologically into two distinct tumor types. Bi-phenotypic hepatocellular carcinoma-cholangiocarcinoma (HCC-CC), although a rare tumor, is important for clinicians to recognize, since treatment options targeting both elements of the tumor are crucial. Imaging findings of bi-phenotypic HCC-CC are not specific and include features of both HCC and CC. A combination of imaging and immuno-histochemical analysis is usually needed to make the diagnosis.
双表型肿瘤是指起源于共同癌症干细胞的肿瘤，具有独特的组织学分化能力，可分化为两种不同的肿瘤类型。双表型肝细胞癌-胆管癌（HCC-CC）虽然是一种罕见肿瘤，但临床医生认识它很重要，因为针对肿瘤两种成分的治疗方案至关重要。双表型HCC-CC的影像学表现不具有特异性，包括HCC和CC的特征。通常需要结合影像学和免疫组织化学分析来做出诊断。
