Bitterman Jacob L, Chung Jay H
Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, 10 Center Drive Building 10 Room 7D14, Bethesda, MD, 20892, USA,
Cell Mol Life Sci. 2015 Apr;72(8):1473-88. doi: 10.1007/s00018-014-1808-8. Epub 2014 Dec 30.
Resveratrol, a polyphenol found in a number of plant-based foods such as red wine, has received a great deal of attention for its diverse array of healthful effects. Beneficial effects of resveratrol are diverse; they include improvement of mitochondrial function, protection against obesity and obesity-related diseases such as type-2 diabetes, suppression of inflammation and cancer cell growth and protection against cardiovascular dysfunction, just to name a few. Investigations into the metabolic effects of resveratrol are furthest along and now include a number of clinical trials, which have yielded mixed results. There are a number of controversies surrounding resveratrol that have not been resolved. Here, we will review these controversies with particular emphasis on its mechanism of metabolic action and how lessons from resveratrol may help develop therapies that harness the effects of resveratrol but without the undesirable properties of resveratrol.
白藜芦醇是一种存在于多种植物性食物（如红酒）中的多酚，因其具有多种有益健康的功效而备受关注。白藜芦醇的有益作用多种多样，包括改善线粒体功能、预防肥胖及肥胖相关疾病（如2型糖尿病）、抑制炎症和癌细胞生长以及预防心血管功能障碍等等。对白藜芦醇代谢作用的研究最为深入，目前已有多项临床试验，结果不一。围绕白藜芦醇存在诸多尚未解决的争议。在此，我们将回顾这些争议，特别强调其代谢作用机制，以及从白藜芦醇中吸取的经验教训如何有助于开发利用白藜芦醇的功效但又不具备其不良特性的疗法。
