Molani-Gol Roghayeh, Rafraf Maryam
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Eur J Nutr. 2024 Jun;63(4):1023-1040. doi: 10.1007/s00394-024-03335-9. Epub 2024 Feb 19.
The evidence for resveratrol's anti-obesity and anti-inflammatory qualities is accumulating, though meta-analyses have reported mixed results. The current umbrella meta-analysis aimed to assess the present evidence and provide an accurate estimate of the overall effects of resveratrol on the anthropometric indices and inflammatory markers.
The Web of Science, PubMed, Scopus, and Google Scholar databases were searched till March 2023. The meta-analysis was performed utilizing a random-effects model. Moreover, the overall strength and quality of the evidence were assessed using the GRADE tool.
The results from 19 meta-analyses investigating 81 unique randomized controlled trials with 4088 participants revealed that resveratrol supplementation reduced the body mass index (ES = - 0.119, 95% CI (- 0.192, - 0.047), p = 0.001), waist circumference (ES = - 0.405, 95% CI [- 0.664, - 0.147], p = 0.002), serum levels of C-reactive protein (ES = - 0.390, 95% CI [- 0.474, - 0.306], p < 0.001), and tumor necrosis factor-α (ES = - 0.455, 95% CI [- 0.592, - 0.318], p < 0.001) in comparison to the control group. The effects of resveratrol on body weight and Interleukin-6 levels of participants were not significant. However, resveratrol administration significantly decreased body weight in trials with intervention duration ≥ 12 weeks [ES = - 0.160, 95% CI (- 0.268, - 0.052)] and supplement dosage ≥ 500 mg/day [ES = - 0.130, 95% CI (- 0.238, - 0.022)].
The findings suggest the beneficial effects of resveratrol supplementation on reducing general and central obesity, as well as decreasing some inflammatory markers. Nevertheless, further high-quality research is required to prove these achievements and also evaluate resveratrol's effects on other inflammatory markers.
尽管荟萃分析报告的结果不一，但白藜芦醇具有抗肥胖和抗炎特性的证据正在不断积累。当前的伞状荟萃分析旨在评估现有证据，并准确估计白藜芦醇对人体测量指标和炎症标志物的总体影响。
检索了科学网、PubMed、Scopus和谷歌学术数据库，直至2023年3月。采用随机效应模型进行荟萃分析。此外，使用GRADE工具评估证据的总体强度和质量。
19项荟萃分析的结果涉及81项独特的随机对照试验，共4088名参与者，结果显示，与对照组相比，补充白藜芦醇可降低体重指数（效应量= -0.119，95%置信区间[-0.192，-0.047]，p = 0.001）、腰围（效应量= -0.405，95%置信区间[-0.664，-0.147]，p = 0.002）、血清C反应蛋白水平（效应量= -0.390，95%置信区间[-0.474，-0.306]，p < 0.001）和肿瘤坏死因子-α水平（效应量= -0.455，95%置信区间[-0.592，-0.318]，p < 0.001）。白藜芦醇对参与者体重和白细胞介素-6水平的影响不显著。然而，在干预持续时间≥12周[效应量= -0.160，95%置信区间(-0.268，-0.052)]和补充剂量≥500毫克/天[效应量= -0.130，95%置信区间(-0.238，-0.022)]的试验中，白藜芦醇给药显著降低了体重。
研究结果表明白藜芦醇补充剂对减轻全身性和中心性肥胖以及降低一些炎症标志物具有有益作用。然而，需要进一步的高质量研究来证实这些成果，并评估白藜芦醇对其他炎症标志物的影响。
