Rezk Mohamed, Gamal Awni, Emara Mahmoud
Obstetrics and Gynecology Department .
Hypertens Pregnancy. 2015 May;34(2):137-44. doi: 10.3109/10641955.2014.982329. Epub 2014 Dec 30.
To assess the maternal and fetal outcome in women with de novo preeclampsia (PE) in comparison to superimposed PE.
This was a prospective 2-year observational study carried out at Menoufia University Hospital, Egypt, in which 164 patients out of 6472 pregnant women were diagnosed with PE (78 with de novo PE and 86 with superimposed PE). Enrolled patients were followed to assess the maternal and fetal outcome.
There was a significant higher women with liver impairment and delivery by caesarean section in the de novo PE group (p < 0.05), with more women with renal impairment and ECG changes in the superimposed PE group (p < 0.05). No significant difference between the two groups regarding the occurrence of eclampsia, blood transfusion, admission to ICU and venous thromboembolism (p > 0.05). There was a significantly higher small for gestational age, prematurity, NICU admission and perinatal mortality in the superimposed PE group (p < 0.05). No significant difference between the two groups regarding the occurrence of placental abruption and intrauterine fetal demise (p > 0.05).
Women with de novo PE have higher risks of liver impairment and delivery by cesarean section. On the other hand, women with superimposed PE have higher risks of poorer fetal outcome.
评估初发型子痫前期（PE）妇女与子痫前期叠加征妇女的母婴结局。
这是一项在埃及曼努菲亚大学医院进行的为期2年的前瞻性观察性研究，6472名孕妇中有164例被诊断为PE（78例为初发型PE，86例为子痫前期叠加征）。对纳入的患者进行随访以评估母婴结局。
初发型PE组肝功能损害及剖宫产分娩的女性显著更多（p<0.05），子痫前期叠加征组肾功能损害及心电图改变的女性更多（p<0.05）。两组在子痫、输血、入住重症监护病房及静脉血栓栓塞的发生率方面无显著差异（p>0.05）。子痫前期叠加征组小于胎龄儿、早产、入住新生儿重症监护病房及围产儿死亡率显著更高（p<0.05）。两组在胎盘早剥及胎儿宫内死亡的发生率方面无显著差异（p>0.05）。
初发型PE妇女肝功能损害及剖宫产分娩的风险更高。另一方面，子痫前期叠加征妇女胎儿结局较差的风险更高。
