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科学之旅:血红蛋白领域的早期教训。

A journey in science: early lessons from the hemoglobin field.

机构信息

Weatherall Institute of Molecular Medicine, Oxford University, Oxford, United Kingdom.

出版信息

Mol Med. 2014 Nov 11;20(1):478-85. doi: 10.2119/molmed.2014.00093.

Abstract

Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to document and preserve these histories. The monographs recount the seminal events as told in the voice of the original investigators who provided the crucial early insight. These essays capture the essence of discovery, chronicling the birth of ideas that created new fields of research; and launched trajectories that persisted and ultimately influenced how disease is prevented, diagnosed, and treated. In this volume, the Cerami Award Monograph is by David J Weatherall, Founder, Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital. A visionary in the field of hemoglobin, this is the story of Professor Weatherall's scientific journey.

摘要

医学和科学领域的真正创新具有历史性和独特性;每一个事件背后的故事都是宝贵的。在分子医学领域,我们设立了安东尼·塞拉米转化医学奖,以记录和保存这些历史。专论以原始研究者的声音讲述了关键的早期见解,叙述了这些开创性事件。这些论文捕捉到了发现的本质,记录了创造新研究领域的思想的诞生;并开启了持续的轨迹,最终影响了疾病的预防、诊断和治疗方式。在这一卷中,塞拉米奖专论的作者是牛津大学分子医学韦瑟罗尔研究所的创始人戴维·J·韦瑟罗尔教授。作为血红蛋白领域的一位有远见的人,这是韦瑟罗尔教授科学之旅的故事。

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本文引用的文献

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The molecular basis of α-thalassemia.α-地中海贫血的分子基础。
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