Bazan J F
Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0448.
Biochem Biophys Res Commun. 1989 Oct 31;164(2):788-95. doi: 10.1016/0006-291x(89)91528-3.
Lymphokine and hematopoietic growth factors control the differentiation and proliferation of diverse cell types by binding to specific cell-surface receptors. Strikingly, the recently elucidated sequences of the interleukin-6 and erythropoietin receptors, and the interleukin-2 receptor beta-chain (p75), display a significant evolutionary resemblance of their extracellular domains. This homology extends to the binding domains of the growth hormone/prolactin class of receptors. Alternatively, little similarity exists between the cytoplasmic extensions of these diverse receptors. I discuss the evolutionary and functional implications of this broad, mosaic receptor relationship, with particular reference to possible structural resemblances between the cognate growth factors.
淋巴因子和造血生长因子通过与特定的细胞表面受体结合来控制多种细胞类型的分化和增殖。引人注目的是，最近阐明的白细胞介素-6、促红细胞生成素受体以及白细胞介素-2受体β链（p75）的序列，显示出它们细胞外结构域在进化上有显著的相似性。这种同源性延伸到生长激素/催乳素类受体的结合结构域。然而，这些不同受体的细胞质延伸部分之间几乎没有相似性。我将讨论这种广泛的、镶嵌式受体关系的进化和功能意义，特别提及相关生长因子之间可能存在的结构相似性。
