Jung Mila, Choi Janggyoo, Chae Hee-Sung, Cho Jae Youl, Kim Young-Dong, Htwe Khin Myo, Lee Woo-Shin, Chin Young-Won, Kim Jinwoong, Yoon Kee Dong
College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea.
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Korea.
Molecules. 2014 Dec 26;20(1):358-65. doi: 10.3390/molecules20010358.
A novel isoflavone glycoside, peseudobatigenin 7-O-[β-d-apiofuranosyl-(1''''→5''')-O-β-d-apiofuranosyl-(1'''→6'')]-β-d-glucopyranoside, namely sympracemoside (1), was isolated from the aerial parts of Symplocos racemosa along with 15 known flavonoids (2-16). Their structures were characterized by Q-TOF mass, optical rotation, UV, 1D and 2D-NMR spectroscopic data. Compounds 3, 9, 16 showed moderate inhibitory activities against NO production with IC50 value of 88.2, 42.1 and 74.3 μM, respectively.
从总状山矾的地上部分分离出一种新型异黄酮苷，即假蝙蝠葛宁7 - O - [β - d - 阿吡喃糖基 - (1''''→5''') - O - β - d - 阿吡喃糖基 - (1'''→6'')] - β - d - 吡喃葡萄糖苷，即总状山矾苷（1），同时还分离出15种已知黄酮类化合物（2 - 16）。通过Q - TOF质谱、旋光度、紫外光谱、一维和二维核磁共振光谱数据对它们的结构进行了表征。化合物3、9、16对一氧化氮生成显示出中等抑制活性，IC50值分别为88.2、42.1和74.3 μM。
