Abbasi Muhammad Athar, Ahmad Viqar Uddin, Zubair Muhammad, Nawaz Sarfraz A, Lodhi Muhammad Arif, Farooq Umar, Choudhary M Iqbal
HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Karachi 75270, Pakistan.
Nat Prod Res. 2005 Jul;19(5):509-15. doi: 10.1080/1478641042000261978.
Phytochemical investigation of Symplocos racemosa resulted in the isolation of a new ethyl substituted glycoside, 1-ethyl brachiose-3'-acetate (1) along with four known compounds ketochaulmoogric acid (2), nonaeicosanol (3), triacontyl palmitate (4) and methyl triacontanoate (5). The substitution of ethyl group on 1 was natural because during the course of extraction and purification ethanol was not used. The structural elucidation of the isolated compounds was based primarily on 1D- and 2D-NMR analysis, including COSY, HMQC, and HMBC correlations. The glycoside 1 and triacontyl palmitate (4) displayed the inhibitory potential against lipoxygenase and urease enzyme, respectively.
对总状山矾进行植物化学研究，分离得到一种新的乙基取代糖苷1-乙基臂形糖-3'-乙酸酯（1）以及四种已知化合物酮麻风油酸（2）、二十九醇（3）、棕榈酸三十烷酯（4）和三十烷酸甲酯（5）。1上乙基的取代是自然发生的，因为在提取和纯化过程中未使用乙醇。分离得到的化合物的结构解析主要基于一维和二维核磁共振分析，包括COSY、HMQC和HMBC相关。糖苷1和棕榈酸三十烷酯（4）分别对脂氧合酶和脲酶显示出抑制潜力。
