Syal Gaurav, Heldenbrand Seth D, Duarte-Rojo Andres
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR; and 2Department of Clinical Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR.
Am J Ther. 2016 Mar-Apr;23(2):e570-1. doi: 10.1097/MJT.0000000000000188.
Newer direct-acting antiviral agents have revolutionized the medical management of chronic hepatitis C. In addition to being extremely efficacious, they report very mild adverse drug reactions from experience in clinical trials. However, because they are relatively new on the horizon, postmarketing surveillance studies refining the safety profile are not yet available. We present a case of seizures as a potential side effect of antiviral therapy with sofosbuvir and simeprevir.
新型直接作用抗病毒药物彻底改变了慢性丙型肝炎的医学治疗方式。除了疗效极佳外，根据临床试验经验，它们的药物不良反应非常轻微。然而，由于它们相对较新，目前尚无完善安全性概况的上市后监测研究。我们报告一例癫痫发作，其可能是索磷布韦和西米普明抗病毒治疗的副作用。
