补充钙预防子痫前期的证据有限：一项荟萃分析与系统评价
Limited evidence for calcium supplementation in preeclampsia prevention: a meta-analysis and systematic review.
作者信息
Tang Reuben, Tang Ing Ching, Henry Amanda, Welsh Alec
机构信息
Department of Maternal-Fetal medicine, Royal Hospital for Women , Sydney , Australia .
出版信息
Hypertens Pregnancy. 2015 May;34(2):181-203. doi: 10.3109/10641955.2014.988353. Epub 2014 Dec 30.
OBJECTIVE
This article synthesises evidence for calcium supplementation in preeclampsia prevention.
METHODS
Major databases and trial registries were searched, and comparisons were made against other meta-analyses.
RESULTS
Calcium supplementation reduced the overall risk of preeclampsia in 10 trials (n = 24 787; risk ratio (RR) 0.62; 95% confidence interval [CI] 0.47-0.81). Its effect was larger in two subgroups: low-baseline calcium intake (RR 0.42 [0.23-0.76]) and increased risk of developing hypertensive disorders (RR 0.36 [0.10-0.98]). This effect was not significant amongst larger studies (RR 0.93 [0.83-1.04]). Funnel plotting suggested possible publication bias.
CONCLUSION
Some evidence for calcium supplementation exists, but its utility is limited by the possibility of publication bias and a lack of large trials.
目的
本文综合了关于补充钙预防子痫前期的证据。
方法
检索了主要数据库和试验注册库，并与其他荟萃分析进行了比较。
结果
在10项试验（n = 24787；风险比（RR）0.62；95%置信区间[CI] 0.47 - 0.81）中，补充钙降低了子痫前期的总体风险。在两个亚组中其效果更大：低基线钙摄入量（RR 0.42 [0.23 - 0.76]）和发生高血压疾病风险增加（RR 0.36 [0.10 - 0.98]）。在规模较大的研究中，这种效果不显著（RR 0.93 [0.83 - 1.04]）。漏斗图提示可能存在发表偏倚。
结论
存在一些补充钙的证据，但其效用受到发表偏倚可能性和缺乏大型试验的限制。
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