From the *Nuclear Medicine Unit, CHR Orléans, †Hôpital Bretonneau, CHRU Hôpitaux de Tours; ‡INSERM U930 and Université François Rabelais de Tours; §Memory Clinic, CMRR, Hôpital Bretonneau; ‖CIC INSERM 1415; and ¶CIC-IT INSERM, CHRU Hôpitaux de Tours, Tours, France.
Clin Nucl Med. 2015 Feb;40(2):e111-6. doi: 10.1097/RLU.0000000000000666.
The aim of this study is to compare regional cerebral metabolic rate of glucose metabolism and amyloid-β density in patients with Alzheimer disease (AD), mild cognitive impairment (MCI), and healthy elderly subjects.
Eighteen patients (including 6 AD, 5 amnestic MCI, and 7 controls) were enrolled at the University Hospital of Tours, France, and submitted to clinical, neuropsychological, and MRI examinations. PET images using F-florbetapir (266 MBq) and F-FDG (185 MBq) were acquired. SUV ratios in specific regions were defined using PMOD3.2 software.
The mean values of F-FDG SUV ratio were significantly lower in frontal, anterior cingulate, and temporal regions in MCI patients than in normal elderly (-15%, -22%, and -11%, respectively). Alzheimer disease patients showed global cerebral metabolic rate of glucose metabolism decrease, especially in parietal and precuneus regions (-15% and -13% compared with healthy control subjects). Only precuneus cortex showed an increased F-florbetapir uptake in AD. There was no other significant regional difference in the amyloid-β density.
In this study, we observed regional brain metabolic changes between MCI, AD, and controls, whereas only precuneus showed an increased amyloid-β density in AD. F-florbetapir PET analysis needs to be visual and global, whereas F-FDG analysis can be regional.
本研究旨在比较阿尔茨海默病（AD）、轻度认知障碍（MCI）和健康老年人患者的局部脑葡萄糖代谢率和淀粉样蛋白-β密度。
法国图尔大学医院招募了 18 名患者（包括 6 名 AD、5 名遗忘型 MCI 和 7 名对照），并进行了临床、神经心理学和 MRI 检查。使用 F-氟比他滨（266 MBq）和 F-FDG（185 MBq）进行 PET 成像。使用 PMOD3.2 软件定义特定区域的 SUV 比值。
与正常老年人相比，MCI 患者的额、前扣带回和颞叶区域的 F-FDG SUV 比值平均值显著降低（分别为-15%、-22%和-11%）。AD 患者表现出全脑葡萄糖代谢率降低，特别是顶叶和楔前叶区域（与健康对照组相比分别为-15%和-13%）。仅在 AD 中，扣带回皮层显示出 F-氟比他滨摄取的增加。淀粉样蛋白-β密度无其他显著的区域差异。
在这项研究中，我们观察到 MCI、AD 和对照组之间的局部脑代谢变化，而只有扣带回显示出 AD 中淀粉样蛋白-β密度的增加。F-氟比他滨 PET 分析需要进行视觉和全面评估，而 F-FDG 分析可以进行区域评估。
