Shinagawa Nagao, Taniguchi Masaaki, Hirata Koichi, Furuhata Tomohisa, Fukuhara Kenichiro, Mizugucwi Tohru, Osanai Hiroyuki, Yanai Yoshiyuki, Hata Fumitake, Kihara Chikasi, Sasaki Kazuaki, Oono Keisuke, Nakamura Masashi, Shibuya Hitoshi, Hasegawa Itaru, Kimura Masami, Watabe Kosho, Kobayashi Yasuhito, Yamaue Hiroki, Hirono Seiko, Takesue Yoshio, Fujiwara Toshiyoshi, Shinoura Susumu, Kimura Hideyuki, Hoshikawa Tsuyoshi, Oshima Hideki, Aikawa Naoki, Sasaki Junichi, Suzuki Masaru, Sekine Kazuhiko, Abe Shinya, Takeyama Hiromitsu, Wakasugi Takehiro, Mashita Keiji, Tanaka Moritsugu, Mizuno Akira, Ishikawa Masakazu, Iwai Akihiko, Saito Takaaki, Muramoto Masayuki, Kubo Shoji, Lee Shigeru, Fukuhara Kenichiro, Iwagaki Hiromi, Tokunaga Naoyuki, Sueda Taijliro, Hiyama Elso, Murakami Yoshiaki, Ohge Hiroki, Uemura Kenichiro, Tsumura Hiroaki, Kanehiro Tetsuya, Takeuchi Hitoshi, Tanakaya Koujn, Iwasaki Mitsuhiro
Tokyo Healthcare University and Postgraduate School.
Jpn J Antibiot. 2014 Oct;67(5):293-334.
Bacteria isolated from surgical infections during the period from April 2010 to March 2011 were investigated in a multicenter study in Japan, and the following results were obtained. In this series, 631 strains including 25 strains of Candida spp. were isolated from 170 (81.7%) of 208 patients with surgical infections. Four hundred and twenty two strains were isolated from primary infections, and 184 strains were isolated from surgical site infection. From primary infections, anaerobic Gram-negative bacteria were predominant, followed by aerobic Gram-negative bacteria, while from surgical site infection aerobic Gram-positive bacteria were predominant, followed by anaerobic Gram-negative bacteria. Among aerobic Gram-positive bacteria, the isolation rate of Enterococcus spp. such as Enterococcus faecalis, Enterococcus faecium, and Enterococcus avium was highest, followed by Streptococcus spp. such as Streptococcus anginosus and Staphylococcus spp. such as Staphylococcus aureus, in this order, from primary infections, while Enterococcus spp. such as E. faecalis and E. faecium was highest, followed by Staphylococcus spp. such as S. aureus from surgical site infection. Among aerobic Gram-negative bacteria, Escherichia coli was the most predominantly isolated from primary infections, followed by Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Pseudomonas aeruginosa in this order, and from surgical site infection, E. coli and R aeruginosa were most predominantly isolated, followed by E. cloacae and K. pneumoniae. Among anaerobic Gram-positive bacteria, the isolation rates of Parvimonas micra, Eggerthella lenta, Streptococcus constellatus, Gemella morbillorum, and Collinsella aerofaciens were the highest from primary infections, and the isolation rate from surgical site infection was generally low. Among anaerobic Gram-negative bacteria, the isolation rate of Bilophila wadsworthia was the highest from primary infections, followed by, Bacteroides fragilis and Bacteroides ovatus, and from surgical site infection, B. fragilis was most predominantly isolated, followed by Bacteroides thetaiotaomnicron, in this order. In this series, vancomycin-resistant MRSA (methicillin-resistant S. aureus), vancomycin-resistant Enterococcus spp. and multidrug-resistant P. aeruginosa were not observed.
在日本的一项多中心研究中，对2010年4月至2011年3月期间从外科感染中分离出的细菌进行了调查，结果如下。在该系列研究中，从208例外科感染患者中的170例（81.7%）分离出631株菌株，其中包括25株念珠菌属菌株。从原发性感染中分离出422株菌株，从手术部位感染中分离出184株菌株。在原发性感染中，厌氧革兰氏阴性菌占主导，其次是需氧革兰氏阴性菌；而在手术部位感染中，需氧革兰氏阳性菌占主导，其次是厌氧革兰氏阴性菌。在需氧革兰氏阳性菌中，粪肠球菌、屎肠球菌和鸟肠球菌等肠球菌属的分离率最高，其次是咽峡炎链球菌等链球菌属和金黄色葡萄球菌等葡萄球菌属，按此顺序排列于原发性感染中；而在手术部位感染中，粪肠球菌和屎肠球菌等肠球菌属的分离率最高，其次是金黄色葡萄球菌等葡萄球菌属。在需氧革兰氏阴性菌中，原发性感染中最常分离出的是大肠埃希菌，其次依次为肺炎克雷伯菌、产酸克雷伯菌、阴沟肠杆菌和铜绿假单胞菌；在手术部位感染中，最常分离出的是大肠埃希菌和铜绿假单胞菌，其次是阴沟肠杆菌和肺炎克雷伯菌。在厌氧革兰氏阳性菌中，微小消化链球菌、迟缓埃格特菌、星座链球菌、麻疹孪生球菌和气单胞菌科林斯菌在原发性感染中的分离率最高，手术部位感染的分离率普遍较低。在厌氧革兰氏阴性菌中，沃兹沃思嗜胆菌在原发性感染中的分离率最高，其次是脆弱拟杆菌和卵形拟杆菌；在手术部位感染中，最常分离出的是脆弱拟杆菌，其次依次为多形拟杆菌。在该系列研究中，未观察到耐万古霉素的耐甲氧西林金黄色葡萄球菌（MRSA）、耐万古霉素的肠球菌属和多重耐药的铜绿假单胞菌。
