非肠球菌：临床特征、毒力因子和抗菌药物耐药性综述。
Non- non- enterococci: a review of clinical manifestations, virulence factors, and antimicrobial resistance.
机构信息
Antimicrobial Resistance and Infectious Diseases (AMRID) Research Laboratory, Murdoch University, Murdoch, Western Australia, Australia.
The Marshall Centre for Infectious Diseases Research and Training, School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
出版信息
Clin Microbiol Rev. 2024 Jun 13;37(2):e0012123. doi: 10.1128/cmr.00121-23. Epub 2024 Mar 11.
Abstract
SUMMARYEnterococci are a diverse group of Gram-positive bacteria that are typically found as commensals in humans, animals, and the environment. Occasionally, they may cause clinically relevant diseases such as endocarditis, septicemia, urinary tract infections, and wound infections. The majority of clinical infections in humans are caused by two species: and . However, there is an increasing number of clinical infections caused by non- non- (NFF) enterococci. Although NFF enterococcal species are often overlooked, studies have shown that they may harbor antimicrobial resistance (AMR) genes and virulence factors that are found in and . In this review, we present an overview of the NFF enterococci with a particular focus on human clinical manifestations, epidemiology, virulence genes, and AMR genes.
摘要
摘要肠球菌是一组多样化的革兰氏阳性细菌，通常作为人类、动物和环境中的共生菌存在。偶尔，它们可能会引起临床上相关的疾病，如心内膜炎、败血症、尿路感染和伤口感染。人类的大多数临床感染是由两个物种引起的： 和 。然而，由非粪肠球菌-屎肠球菌（NFF）肠球菌引起的临床感染数量正在不断增加。尽管 NFF 肠球菌种通常被忽视，但研究表明，它们可能携带在 和 中发现的抗微生物药物耐药（AMR）基因和毒力因子。在这篇综述中，我们介绍了 NFF 肠球菌的概述，特别关注人类的临床表现、流行病学、毒力基因和 AMR 基因。
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