Kurihara M, Tokunaga Y, Ochi A, Kawaguchi T, Tsutsumi K, Shigematsu K, Niwa M, Mori K
Department of Neurosurgery, Nagasaki University School of Medicine, Japan.
No To Shinkei. 1989 Jul;41(7):719-25.
By using quantitative autoradiographic techniques, receptors for insulin-like growth factor I (IGF-I) and epidermal growth factor (EGF) were analyzed in 13 samples of human brain tumors (4 low grade astrocytomas, 7 glioblastomas, 1 anaplastic ependymoma and 1 medulloblastoma). High number of specific binding sites for IGF-I and EGF were homogeneously present in tissue sections derived from glioblastoma. In low grade astrocytoma, relatively high numbers of binding site for EGF were observed, but there was no significant difference in concentrations of IGF-I binding sites between tumors and control cortex. In medulloblastoma, only IGF-I binding sites were present. These observations might indicate that both IGF-I and EGF are involved in the growth modulation of human gliomas possibly through paracrine or autocrine mechanisms. Antagonists to growth factors or monoclonal antibody against those receptors could have the way for therapeutic application for gliomas.
通过使用定量放射自显影技术，对13例人脑肿瘤样本（4例低级别星形细胞瘤、7例胶质母细胞瘤、1例间变性室管膜瘤和1例髓母细胞瘤）中的胰岛素样生长因子I（IGF-I）和表皮生长因子（EGF）受体进行了分析。在源自胶质母细胞瘤的组织切片中，大量的IGF-I和EGF特异性结合位点均匀存在。在低级别星形细胞瘤中，观察到相对较高数量的EGF结合位点，但肿瘤与对照皮质之间IGF-I结合位点的浓度没有显著差异。在髓母细胞瘤中，仅存在IGF-I结合位点。这些观察结果可能表明，IGF-I和EGF可能通过旁分泌或自分泌机制参与人类胶质瘤的生长调节。生长因子拮抗剂或针对这些受体的单克隆抗体可能为胶质瘤的治疗应用提供途径。
