Sara V R, Prisell P, Sjögren B, Persson L, Boethius J, Enberg G
Cancer Lett. 1986 Sep;32(3):229-34. doi: 10.1016/0304-3835(86)90174-6.
The somatomedins (IGF-1/IGF-2) are a family of growth-promoting hormones which have been identified in the human central nervous system where their specific receptors are distributed. The present study identified somatomedin receptors in glioblastoma and compared them with those found in normal brain. A significant enhancement in the binding of 125I-IGF-2 but not 125I-IGF-1 to glioblastoma membranes was found. A fourfold increase in IGF-2 receptor concentration was observed. These findings indicate enhanced expression of the IGF-2 receptor in glioblastoma.
生长调节素（IGF-1/IGF-2）是一类具有促进生长作用的激素家族，已在人类中枢神经系统中被鉴定出来，其特异性受体分布于此。本研究在胶质母细胞瘤中鉴定出了生长调节素受体，并将其与正常脑组织中的受体进行了比较。结果发现，125I-IGF-2而非125I-IGF-1与胶质母细胞瘤细胞膜的结合显著增强。观察到IGF-2受体浓度增加了四倍。这些发现表明胶质母细胞瘤中IGF-2受体的表达增强。
