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[急性呼吸窘迫综合征的发病机制与靶向治疗]

[Pathogenesis and target therapy of acute respiratory distress syndrome].

作者信息

Moroz V V, Vlasenko A V, Golubev A M

出版信息

Anesteziol Reanimatol. 2014 Jul-Aug;59(4):45-52.

PMID:25549486
Abstract

The paper summarizes results of experimental studies and clinical observations of the pathogenesis and effectiveness of respiratory, non-respiratory and pharmacological treatment methods for acute respiratory distress syndrome caused by direct and indirect damaging factors. The article deals with differences and peculiarities of morphological changes and lung functional disorders, clinical, laboratory and instrumental signs of various origins in ARDS and justifies necessity of differential diagnosis and differential treatment of ARDS, depending on the reasons for its development. Furthermore the article discusses an algorithm for differential diagnosis and differential treatment for ARDS caused by direct and indirect damaging factors.

摘要

本文总结了由直接和间接损伤因素引起的急性呼吸窘迫综合征的发病机制以及呼吸、非呼吸和药物治疗方法有效性的实验研究和临床观察结果。文章探讨了急性呼吸窘迫综合征中不同病因的形态学变化和肺功能障碍的差异与特点、临床、实验室及器械检查体征,并论证了根据急性呼吸窘迫综合征的发病原因进行鉴别诊断和个体化治疗的必要性。此外,文章还讨论了针对直接和间接损伤因素所致急性呼吸窘迫综合征的鉴别诊断及个体化治疗方案。

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