Gong Xiu, Wu Jinsong, Mao Ying, Zhou Liangfu
Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China. Email:
Zhonghua Yi Xue Za Zhi. 2014 Oct 28;94(39):3102-6.
The hypothesis that "cell phone induces brain tumor" has become a target of much controversy for several decades and is still a matter of debate even now. We aim to make a systematic review and meta-analysis based on published studies on glioma to identify current evidences for evaluating mobile phones and glioma risk, especially on long-term use of mobile phones.
The study was conducted according to the Cochrane systematic review methods and reported according to the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) statement according to a prospective research protocol accessed via http://www.crd.york.ac.uk/prospero. The software RevMan 5 was used for statistic analysis. Latency and lateralization were used for the examining the dose-response relationship.
Overall evidence suggested the increased risk of glioma among long-term ipsilateral users of mobile phone with an odds ratio (OR) of 1.46[1.12, 1.92] based on meta-analysis. Especially, for low-grade glioma, long-term use yielded an OR value of 2.27 [1.81, 2.85].
The evidence is currently insufficient on this issue, especially on long-term use of mobile phone. Neither a definite answer nor a clear explanation may be offered for the relationship. And larger prospective trials are warranted.
“手机诱发脑肿瘤”这一假说几十年来一直备受争议，至今仍是一个争论焦点。我们旨在基于已发表的关于胶质瘤的研究进行系统综述和荟萃分析，以确定当前评估手机与胶质瘤风险，特别是长期使用手机风险的证据。
本研究按照Cochrane系统综述方法进行，并根据通过http://www.crd.york.ac.uk/prospero获取的前瞻性研究方案，依照PRISMA（系统综述和荟萃分析优先报告项目）声明进行报告。使用RevMan 5软件进行统计分析。采用潜伏期和偏侧化来检验剂量反应关系。
总体证据表明，基于荟萃分析，长期同侧使用手机的人群患胶质瘤的风险增加，优势比（OR）为1.46[1.12, 1.92]。特别是对于低级别胶质瘤，长期使用的OR值为2.27[1.81, 2.85]。
目前关于这个问题的证据不足，特别是在长期使用手机方面。对于两者之间的关系，既无法给出明确答案，也没有清晰的解释。需要进行更大规模的前瞻性试验。
