血管紧张素转换酶活性存在于内皮剥脱的主动脉中。
Angiotensin converting enzyme activity is present in the endothelium-denuded aorta.
作者信息
Pipili E, Manolopoulos V G, Catravas J D, Maragoudakis M E
机构信息
University of Patras, School of Medicine, Department of Pharmacology, Greece.
出版信息
Br J Pharmacol. 1989 Oct;98(2):333-5. doi: 10.1111/j.1476-5381.1989.tb12599.x.
Abstract
Angiotensin converting enzyme activity was measured in intact aortic rings utilizing the synthetic tripeptide [3H]-benzoyl-Phe-Ala-Pro as the substrate. Intact aortic rings possessed angiotensin converting enzyme activity which was blocked by captopril. Enzyme activity was reduced by approximately 30% after removal of the endothelium by chemical or mechanical methods. The remaining activity was also captopril-sensitive. These results suggest that in addition to endothelium, angiotensin converting enzyme activity is present in other vascular cells and may contribute to the metabolism of angiotensin I generated within the vessel wall.
摘要
利用合成三肽[3H]-苯甲酰-苯丙氨酸-丙氨酸-脯氨酸作为底物，在完整的主动脉环中测量血管紧张素转换酶活性。完整的主动脉环具有血管紧张素转换酶活性，该活性可被卡托普利阻断。通过化学或机械方法去除内皮后，酶活性降低约30%。剩余的活性也对卡托普利敏感。这些结果表明，除了内皮细胞外，血管紧张素转换酶活性还存在于其他血管细胞中，可能有助于血管壁内生成的血管紧张素I的代谢。
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