INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal; CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal.
INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal.
Adv Drug Deliv Rev. 2015 Sep 15;92:53-70. doi: 10.1016/j.addr.2014.12.004. Epub 2014 Dec 27.
The vaginal delivery of various drugs is well described and its relevance established in current medical practice. Alongside recent advances and achievements in the fields of pharmaceutical nanotechnology and nanomedicine, there is an increasing interest in the potential use of different nanocarriers for the delivery of old and new pharmacologically active molecules with either therapeutic or prophylactic purposes. Nanosystems of polymeric nature in particular have been investigated over the last years and their interactions with mucosal fluids and tissues, as well as genital tract biodistribution upon vaginal administration, are now better understood. While different applications have been envisioned, most of the current research is focusing in the development of nano-formulations with the potential to inhibit the vaginal transmission of HIV upon sexual intercourse. The present work focuses its discussion on the potential and perils of polymer-based nanocarriers for the vaginal administration of different pharmacologically active molecules.
各种药物的阴道给药方法已有很好的描述，并且在当前的医学实践中得到了证实。随着药物纳米技术和纳米医学领域的最新进展和成就，人们对不同纳米载体在传递具有治疗或预防目的的新旧药理活性分子方面的潜在用途越来越感兴趣。近年来，人们对聚合态纳米系统进行了研究，现在对其与黏膜液和组织的相互作用以及经阴道给药后的生殖道生物分布有了更好的了解。虽然已经设想了不同的应用，但目前的大部分研究都集中在开发纳米制剂上，这些纳米制剂有望在性行为时抑制 HIV 的阴道传播。本工作重点讨论了基于聚合物的纳米载体在阴道给予不同药理活性分子方面的潜力和风险。
