Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Rio 26510, Greece; Foundation for Research and Technology Hellas, Institute of Chemical Engineering Sciences, FORTH/ICE-ΗΤ, Rio 26504, Greece.
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Rio 26510, Greece.
Adv Drug Deliv Rev. 2015 Sep 15;92:123-45. doi: 10.1016/j.addr.2015.03.015. Epub 2015 Apr 7.
A review of the recent outcomes regarding technologies to prevent vaginal transmission of HIV, mainly by using antiretroviral (ARV) drugs formulated as microbicides. An introduction about the HIV transmission mechanisms by the vaginal route is included, together with the recent challenges faced for development of successful microbicide products. The outcomes of clinical evaluations are mentioned, and the different formulation strategies studied to-date, with the requirements, advantages, disadvantages and limitations of each dosage-form type, are presented. Finally, the recent attempts to apply various types of nanotechnologies in order to develop advanced microbicide-products and overcome existing limitations, are discussed.
对预防 HIV 通过阴道传播的技术（主要是通过使用作为杀微生物剂的抗逆转录病毒药物）的最新结果进行综述。文中包含有关通过阴道途径传播 HIV 的机制的介绍，以及为开发成功的杀微生物剂产品而面临的最新挑战。提到了临床评估的结果，并介绍了迄今为止研究的不同配方策略，以及每种剂型的要求、优点、缺点和局限性。最后，讨论了最近尝试应用各种类型的纳米技术来开发先进的杀微生物剂产品并克服现有局限性的情况。
