From the Institute of Cellular Medicine, Newcastle Magnetic Resonance Centre (D.G.J., L.P., A.M.B., R.T., K.G.H., M.I.T.); MRC Centre for Ageing and Vitality (D.G.J., M.I.T.), and Department of Cardiology, Freeman Hospital (G.A.M.), Newcastle University, Newcastle upon Tyne, United Kingdom; and Institute for Genetic Medicine, Newcastle upon Tyne, United Kingdom (G.A.M.).
Circ Cardiovasc Imaging. 2014 Dec 30;8(1). doi: 10.1161/CIRCIMAGING.114.002086. Print 2015 Jan.
Higher levels of physical activity are associated with reduced cardiovascular mortality but its effect on age-related changes in cardiac structure and function is unknown. The present study defines the effect of daily physical activity on age-related changes in cardiac structure, function, metabolism, and performance in healthy women.
Sixty-three healthy women were grouped according to age (young, 20-30 years, n=21; middle, 40-50 years, n=22; and older, 65-81 years, n=20) and daily physical activity level (low active<7500 and high active>12,500 steps/d). Participants underwent cardiac MRI including tissue tagging and 31P spectroscopy and exercise testing with noninvasive central hemodynamic measurements. Aging was associated with increased concentric remodeling (P<0.01) and left ventricular torsion (P<0.01), and a decline in diastolic function (P<0.01), cardiac phosphocreatine:ATP ratio (P<0.01), peak exercise cardiac power output (P<0.01), and O2 consumption (P<0.01). Older high-active women demonstrated a phosphocreatine:ATP ratio and relative peak O2 consumption similar to young low-active women, and 23% and 26% higher than older low-active women (phosphocreatine:ATP ratio, 1.9±0.2 versus 1.4±0.1; P<0.05 and O2 consumption, 24.1±3.8 versus 17.8±2.0 mL/[kg·min]; P<0.01). In older women, physical activity had no effect on eccentricity ratio (0.9±0.2 versus 0.8±0.1 g/mL; P=0.19), E/A ratio (1.3±0.5 versus 1.4±0.5; P=0.66), torsion (7.6±1.7 versus 8.0°±2.1°; P=0.20), and peak cardiac power output (3.4±0.7 versus 3.4±0.8 W; P=0.91).
A higher level of daily physical activity preserves cardiac metabolism and exercise capacity with aging but has limited effect on age-related changes in concentric remodeling, diastolic function, and cardiac performance.
更高水平的身体活动与心血管死亡率降低有关，但它对心脏结构和功能的与年龄相关的变化的影响尚不清楚。本研究定义了日常身体活动对健康女性心脏结构、功能、代谢和性能的与年龄相关的变化的影响。
根据年龄（年轻，20-30 岁，n=21；中年，40-50 岁，n=22；老年，65-81 岁，n=20）和日常身体活动水平（低活动<7500 步/天和高活动>12500 步/天），将 63 名健康女性分为三组。参与者接受心脏 MRI 检查，包括组织标记和 31P 光谱检查，以及无创中心血液动力学测量的运动测试。随着年龄的增长，出现了向心性重构（P<0.01）和左心室扭转（P<0.01）的增加，舒张功能（P<0.01）、心脏磷酸肌酸：ATP 比（P<0.01）、峰值运动心输出量（P<0.01）和 O2 消耗（P<0.01）下降。与年轻的低活动女性相比，老年高活动女性的磷酸肌酸：ATP 比和相对峰值 O2 消耗相似，比老年低活动女性高 23%和 26%（磷酸肌酸：ATP 比，1.9±0.2 与 1.4±0.1；P<0.05 和 O2 消耗，24.1±3.8 与 17.8±2.0 mL/[kg·min]；P<0.01）。在老年女性中，体力活动对偏心率（0.9±0.2 与 0.8±0.1 g/mL；P=0.19）、E/A 比（1.3±0.5 与 1.4±0.5；P=0.66）、扭转（7.6±1.7 与 8.0°±2.1°；P=0.20）和峰值心输出量（3.4±0.7 与 3.4±0.8 W；P=0.91）没有影响。
更高水平的日常身体活动可以随着年龄的增长保持心脏代谢和运动能力，但对与年龄相关的向心性重构、舒张功能和心脏功能的变化影响有限。
