Nishida Sachiyo, Hirohashi Yoshihiko, Torigoe Toshihiko, Nojima Masanori, Inoue Ryuta, Kitamura Hiroshi, Tanaka Toshiaki, Asanuma Hiroko, Sato Noriyuki, Masumori Naoya
Department of Pathology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo, Japan Department of Urology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo, Japan.
Department of Pathology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo, Japan
Anticancer Res. 2015 Jan;35(1):413-8.
We previously found that prostate cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) express hepatocyte growth factor (HGF) and that the HGF/c-MET proto-oncogene product (c-MET) signal has a role in the maintenance of prostate CSCs/CICs in an autocrine fashion. HGF is, thus, a novel marker for prostate CSCs/CICs. We hypothesized that high expression of HGF might be related to early recurrence of prostate cancer after radical prostatectomy, and the purpose of the present study was to evaluate the relationship between expression of HGF in prostate tissues and biochemical recurrence after radical prostatectomy. One hundred-one patients with prostate cancer who underwent open or laparoscopic radical prostatectomy from November 2008 to October 2011 with an adequate prostate-specific antigen (PSA) follow-up period, were investigated. Immunohistochemical staining of HGF was compared to biochemical recurrence after radical prostatectomy. Patients with tumors exhibiting HGF positivity of 5% or more had a significantly shorter biochemical recurrence-free period than that of patients whose tumor HGF positivity was less than 5% (p=0.001). In multivariate Cox regression, preoperative PSA and HGF positivity were independent predictors of biochemical recurrence following prostatectomy. Our finding suggests a direct link between expression of HGF, a novel prostate marker of CSCs/CICs, and biochemical recurrence after radical prostatectomy in patients with prostate cancer.
我们之前发现，前列腺癌干细胞样细胞（CSCs）/癌症起始细胞（CICs）表达肝细胞生长因子（HGF），且HGF/c-MET原癌基因产物（c-MET）信号以自分泌方式在维持前列腺CSCs/CICs中发挥作用。因此，HGF是前列腺CSCs/CICs的一种新型标志物。我们推测HGF的高表达可能与前列腺癌根治术后的早期复发有关，本研究的目的是评估前列腺组织中HGF表达与前列腺癌根治术后生化复发之间的关系。对2008年11月至2011年10月期间接受开放或腹腔镜前列腺癌根治术且有足够前列腺特异性抗原（PSA）随访期的101例前列腺癌患者进行了调查。将HGF的免疫组化染色结果与前列腺癌根治术后的生化复发情况进行比较。肿瘤HGF阳性率达到或超过5%的患者无生化复发生存期显著短于肿瘤HGF阳性率低于5%的患者（p=0.001）。在多变量Cox回归分析中，术前PSA和HGF阳性是前列腺切除术后生化复发的独立预测因素。我们的研究结果表明，CSCs/CICs的新型前列腺标志物HGF的表达与前列腺癌患者前列腺癌根治术后的生化复发之间存在直接联系。
