基于环糊精-多糖的眼部抗真菌原位凝胶给药系统。
Cyclodextrin-polysaccharide-based, in situ-gelled system for ocular antifungal delivery.
机构信息
Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Santiago de Compostela (USC), Praza Seminario de Estudos Galegos s/n, Santiago de Compostela, 1570, Spain ; Pharmacy Department, Xerencia de Xestión Integrada de Santiago de Compostela, SERGAS, Travesía Choupana s/n, Santiago de Compostela, 15706, Spain.
Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Santiago de Compostela (USC), Praza Seminario de Estudos Galegos s/n, Santiago de Compostela, 1570, Spain.
出版信息
Beilstein J Org Chem. 2014 Dec 8;10:2903-11. doi: 10.3762/bjoc.10.308. eCollection 2014.
Fluconazole was studied with two different hydrophilic cyclodextrins (hydroxypropyl-β-cyclodextrin (HPBCD) and sulfobutyl ether-β-cyclodextrin (SBECD)) for the formation of inclusion complexes. HPBCD and SBECD showed low cell cytotoxicity in human keratocytes as assessed by the label-free xCELLigence system for real-time monitoring. The fluconazole-HPBCD complex was incorporated into an ion-sensitive ophthalmic gel composed of the natural polysaccharides gellan gum and κ-carrageenan. This system showed good bioadhesive properties and effective control of fluconazole release.
氟康唑与两种不同的亲水性环糊精（羟丙基-β-环糊精（HPBCD）和磺丁基醚-β-环糊精（SBECD））进行了研究，以形成包合物。通过无标记 xCELLigence 系统实时监测，评估了人角膜细胞中的细胞毒性，结果表明 HPBCD 和 SBECD 的细胞毒性较低。将氟康唑-HPBCD 复合物掺入由天然多糖结冷胶和κ-卡拉胶组成的离子敏感眼科凝胶中。该系统具有良好的生物黏附性能和对氟康唑释放的有效控制。
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