Omidian Hossein, Akhzarmehr Arnavaz, Gill Erma J
Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Gels. 2025 Feb 28;11(3):177. doi: 10.3390/gels11030177.
Cyclodextrin (CD)-hydrogel hybrids have emerged as versatile and multifunctional drug delivery systems, offering enhanced solubility, controlled drug release, and improved bioavailability. By combining the inclusion complexation properties of CDs with the swelling and retention capabilities of hydrogels, these hybrid systems overcome key challenges in conventional drug formulations. This review explores CD composition, hydrogel polymer selection, fabrication techniques, key drug release factors, and real-world therapeutic applications. Additionally, the latest advancements in stimuli-responsive hydrogels, nanogels, and microneedle-based drug delivery are discussed. While CD-hydrogel systems demonstrate significant potential, scalability, regulatory hurdles, and clinical translation remain key challenges. Future research should focus on smart hydrogels, improved drug loading strategies, and enhanced clinical validation to bridge the gap between laboratory innovations and commercial applications.
环糊精（CD）-水凝胶杂化物已成为多功能的药物递送系统，具有增强的溶解性、可控的药物释放和提高的生物利用度。通过将环糊精的包合络合特性与水凝胶的溶胀和保留能力相结合，这些杂化系统克服了传统药物制剂中的关键挑战。本综述探讨了环糊精的组成、水凝胶聚合物的选择、制备技术、关键药物释放因素以及实际治疗应用。此外，还讨论了刺激响应性水凝胶、纳米凝胶和基于微针的药物递送的最新进展。虽然环糊精-水凝胶系统显示出巨大的潜力，但可扩展性、监管障碍和临床转化仍然是关键挑战。未来的研究应专注于智能水凝胶、改进的药物负载策略和增强的临床验证，以弥合实验室创新与商业应用之间的差距。
