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1
Inflammatory angiomyolipoma of the liver: an unusual case suggesting relationship to IgG4-related pseudotumor.肝脏炎性血管平滑肌脂肪瘤：1例罕见病例提示与IgG4相关性假瘤有关。
Int J Clin Exp Pathol. 2013;6(4):771-9. Epub 2013 Mar 15.
2
Cathepsin K expression in a wide spectrum of perivascular epithelioid cell neoplasms (PEComas): a clinicopathological study emphasizing extrarenal PEComas.广泛的血管周上皮样细胞肿瘤（PEComas）中组织蛋白酶 K 的表达：强调肾外 PEComas 的临床病理研究。
Histopathology. 2013 Mar;62(4):642-50. doi: 10.1111/his.12059. Epub 2013 Feb 5.
3
Inflammatory angiomyolipoma of the liver: a rare hepatic tumor.肝脏炎性血管平滑肌脂肪瘤：一种罕见的肝肿瘤。
Diagn Pathol. 2012 Sep 15;7:122. doi: 10.1186/1746-1596-7-122.
4
HMB-45 negative clear cell perivascular epithelioid cell tumor of the skin.皮肤HMB-45阴性透明细胞血管周上皮样细胞肿瘤
Acta Dermatovenerol Croat. 2012;20(1):27-9.
5
A distinctive subset of PEComas harbors TFE3 gene fusions.具有独特特征的上皮样血管平滑肌脂肪瘤包含 TFE3 基因融合。
Am J Surg Pathol. 2010 Oct;34(10):1395-406. doi: 10.1097/PAS.0b013e3181f17ac0.
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Inflammatory angiomyolipomas of the liver: a clinicopathologic and immunohistochemical analysis of 5 cases.肝脏炎性血管平滑肌脂肪瘤：5 例临床病理和免疫组化分析。
Ann Diagn Pathol. 2010 Aug;14(4):240-6. doi: 10.1016/j.anndiagpath.2010.03.002. Epub 2010 Jun 11.
7
Chromosomal imbalances detected by comparative genomic hybridization provide evidence that HMB-45-negative uterine angiomyolipomas belong to the PEComa family.通过比较基因组杂交检测到的染色体失衡提供了证据，表明HMB - 45阴性的子宫血管平滑肌脂肪瘤属于PEComa家族。
Histopathology. 2010 Jun;56(7):974-7. doi: 10.1111/j.1365-2559.2010.03567.x.
8
Perivascular epithelioid cell tumor of the nasal cavity with TFE3 expression.鼻腔伴TFE3表达的血管周上皮样细胞瘤
Pathol Int. 2009 Oct;59(10):769-70. doi: 10.1111/j.1440-1827.2009.02443.x.
9
Perivascular epithelioid cell neoplasms: pathology and pathogenesis.血管周上皮样细胞瘤：病理学与发病机制
Hum Pathol. 2010 Jan;41(1):1-15. doi: 10.1016/j.humpath.2009.05.011. Epub 2009 Jul 15.
10
Perivascular epithelioid cell tumor.血管周上皮样细胞肿瘤
Arch Pathol Lab Med. 2009 Apr;133(4):648-54. doi: 10.5858/133.4.648.

伴有组织蛋白酶K和TFE3表达的肝脏前黑素小体阴性炎性血管平滑肌脂肪瘤

Premelanosome-negative inflammatory angiomyolipoma of liver with expression of cathepsin K and TFE3.

作者信息

Sun Ke, Zhao Ming, Yao Hongtian, Wang Lijun, Wei Jianfeng

机构信息

Department of Pathology, The First Affiliated Hospital, Zhengjiang University Medicine School Hangzhou 310003, Zhejiang, P. R. China.

Department of Pathology, Zhejiang Provincial People's Hospital Hangzhou 310014, Zhejiang, P. R. China.

出版信息

Int J Clin Exp Pathol. 2014 Oct 15;7(11):8170-5. eCollection 2014.

PMID:25550868
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4270569/
Abstract

We report the first case of inflammatory variant of hepatic angiomyolipoma (AML) with expression of transcription factor E3 (TFE3) protein but negativity for HMB45 and melan A in a 62-year-old female. Imaging studies revealed a tumor in the left lobe of liver, sized 5.8 cm in maximum diameter. Microscopically, the lesion was composed of large polygonal or epithelioid cells with copious eosinophilic granular cytoplasm. There was a very prominent stromal lymphoplasmacytic infiltrate. Immunohistochemically, the tumor cells showed very strong and diffuse positivity for smooth muscle actin, and cathepsin K, while S-100 protein, keratin, desmin, HMB45 and Melan-A are negative. However, there was multifocal and very convincing nuclear positivity for TFE3, thus confirms the diagnosis.

摘要

我们报告了首例肝血管平滑肌脂肪瘤（AML）炎症变体病例，该病例为一名62岁女性，其转录因子E3（TFE3）蛋白呈阳性表达，但HMB45和黑素A呈阴性。影像学检查显示肝脏左叶有一个肿瘤，最大直径为5.8厘米。显微镜下，病变由具有丰富嗜酸性颗粒细胞质的大的多边形或上皮样细胞组成。有非常明显的间质淋巴细胞和浆细胞浸润。免疫组织化学显示，肿瘤细胞对平滑肌肌动蛋白和组织蛋白酶K呈非常强烈且弥漫性阳性，而S-100蛋白、角蛋白、结蛋白、HMB45和黑素A均为阴性。然而，TFE3呈多灶性且非常令人信服的核阳性，从而确诊。