Massachusetts General Hospital, Clinical Trials Network and Institute and Depression Clinical and Research Program, 1 Bowdoin Square, 6th Fl, Boston, MA 02114
J Clin Psychiatry. 2014 Dec;75(12):1419-21. doi: 10.4088/JCP.14ac09610.
Mental illness accounts for 7.4% of the total disease burden worldwide-more than HIV/AIDS, tuberculosis, or diabetes-making it the leading cause of years lost to disability. Depressive disorders make up 40.5% of that disability, the most of all mental illnesses. Despite the devastating global effects of depression, a report on approval trends by the US Food and Drug Administration (FDA) found that new molecular entities (NMEs) approved for targeting psychiatric illness peaked in the 1960s and have been declining since.
精神疾病占全球疾病总负担的 7.4%——高于艾滋病毒/艾滋病、结核病或糖尿病——使其成为导致残疾年数损失的主要原因。抑郁障碍占残疾总数的 40.5%，是所有精神疾病中占比最高的。尽管抑郁症对全球造成了破坏性影响，但美国食品和药物管理局 (FDA) 的一份关于批准趋势的报告发现，针对精神疾病的新分子实体 (NME) 的批准在 20 世纪 60 年代达到顶峰，此后一直在下降。
