丹曲林，一种治疗阿尔茨海默病的药物？
Dantrolene, a treatment for Alzheimer disease?
作者信息
Liang Li, Wei Huafeng
机构信息
*Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA †Department of Medicinal Chemistry, School of Pharmacy, The Fourth Military Medical School, Xi'an, Shaanxi, China.
出版信息
Alzheimer Dis Assoc Disord. 2015 Jan-Mar;29(1):1-5. doi: 10.1097/WAD.0000000000000076.
Abstract
Alzheimer disease (AD) is a fatal progressive disease and the most common form of dementia without effective treatments. Previous studies support that the disruption of endoplasmic reticulum Ca through overactivation of ryanodine receptors plays an important role in the pathogenesis of AD. Normalization of intracellular Ca homeostasis could be an effective strategy for AD therapies. Dantrolene, an antagonist of ryanodine receptors and an FDA-approved drug for clinical treatment of malignant hyperthermia and muscle spasms, exhibits neuroprotective effects in multiple models of neurodegenerative disorders. Recent preclinical studies consistently support the therapeutic effects of dantrolene in various types of AD animal models and were summarized in the current review.
摘要
阿尔茨海默病（AD）是一种致命的进行性疾病，也是最常见的痴呆形式，目前尚无有效治疗方法。先前的研究表明，通过过度激活兰尼碱受体导致内质网钙紊乱在AD发病机制中起重要作用。恢复细胞内钙稳态可能是AD治疗的有效策略。丹曲林是兰尼碱受体的拮抗剂，是一种经美国食品药品监督管理局（FDA）批准用于临床治疗恶性高热和肌肉痉挛的药物，在多种神经退行性疾病模型中具有神经保护作用。最近的临床前研究一致支持丹曲林在各种类型的AD动物模型中的治疗效果，本综述对此进行了总结。
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