Chernov V N, Belik B M, Efanov S Iu
Vestn Khir Im I I Grek. 2014;173(4):35-8.
Clinical and laboratory signs of abdominal sepsis and endotoxicosis were noted in 194 examined patients with diffuse peritonitis. It was stated that pathogenesis of visceral functions mainly expressed as a splanchnic blood circulation disturbance, massive translocation of gut organisms in portal bloodstream and the functional liver insufficiency particularly marked as form of macrophage liver insufficiency. The complex program of liver rehabilitation should be included in standards of treatment of the patients with diffuse peritonitis. It should be based on preventive measures of the enteral detoxication and microbial decontamination of small intestine and at the same time the intraportal transsubilical infusion correcting therapy has to be applied.
在194例弥漫性腹膜炎患者中观察到腹部脓毒症和内毒素血症的临床及实验室体征。结果表明，内脏功能的发病机制主要表现为内脏血液循环紊乱、肠道微生物大量转移至门静脉血流以及功能性肝功能不全，尤其是表现为巨噬细胞性肝功能不全的形式。肝脏康复的综合方案应纳入弥漫性腹膜炎患者的治疗标准中。该方案应基于小肠肠内解毒和微生物净化的预防措施，同时必须采用门静脉经脐下输注纠正疗法。
