研究肠易激综合征患者血清巨噬细胞移动抑制因子和单核细胞趋化蛋白-1水平。
Investigation of serum macrophage migration inhibitor factor and monocyte chemotactic protein-1 levels in irritable bowel syndrome.
机构信息
Department of Biochemistry, Namık Kemal University, Tekirdağ, Turkey.
出版信息
Turk J Med Sci. 2014;44(6):967-71. doi: 10.3906/sag-1302-90.
AIM
Irritable bowel syndrome (IBS), a functional disorder of the bowel, has been thought to result from immune activation. The aim of this study was to evaluate macrophage migration inhibitory factor (MMIF) and monocyte chemotactic protein-1 (MCP-1) levels in IBS patients.
MATERIALS AND METHODS
We enrolled 30 IBS patients and 30 healthy controls. The MMIF and MCP-1 levels of all patients and controls were detected using commercial enzyme-linked immunosorbent assay kits.
RESULTS
Serum MMIF and MCP-1 levels were markedly higher in IBS patients than in controls. White blood cell, neutrophil, lymphocyte, monocyte, eosinophil, and basophil counts did not differ significantly between groups.
CONCLUSION
These results show that alterations in MMIF and MCP-1 affect the proinflammatory process. They also suggest that MMIF and MCP-1 may play a substantial role in IBS.
目的
肠易激综合征（IBS）是一种肠道功能障碍，被认为是由免疫激活引起的。本研究旨在评估巨噬细胞移动抑制因子（MMIF）和单核细胞趋化蛋白-1（MCP-1）在 IBS 患者中的水平。
材料和方法
我们招募了 30 名 IBS 患者和 30 名健康对照者。使用商业酶联免疫吸附试验试剂盒检测所有患者和对照者的 MMIF 和 MCP-1 水平。
结果
IBS 患者的血清 MMIF 和 MCP-1 水平明显高于对照组。两组间白细胞、中性粒细胞、淋巴细胞、单核细胞、嗜酸性粒细胞和嗜碱性粒细胞计数无显著差异。
结论
这些结果表明，MMIF 和 MCP-1 的改变影响了促炎过程。它们还表明，MMIF 和 MCP-1 可能在 IBS 中起重要作用。
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