Department of General Surgery, Ankara Atatürk Education and Research Hospital, Ankara, Turkey.
Turk J Med Sci. 2014;44(6):1002-9. doi: 10.3906/sag-1312-56.
BACKGROUND/AIM: To investigate the reliability of fine-needle aspiration biopsy (FNAB) in thyroid nodules and benign/malignant discrimination, particularly in large nodules.
A retrospective analysis of 1466 nodules in 402 patients with thyroid nodules who underwent thyroid surgery was made. The pathologic results of the thyroid nodules from preoperative FNAB and postoperative surgical pathology results were compared.
FNAB was found to be in accordance with the postoperative pathologic results. A concordance between the FNAB and postoperative pathologic results, particularly in nodules less than 3 cm in size, was detected. However, a similar finding was not detected in nodules larger than 3 cm in size. The rates, calculated without taking into consideration the nodule dimensions, were found to be: sensitivity, 47.65%; specificity, 93.98%; false-negative, 52.35%; and false-positive 6.02%
In our experience, the false-negative rate of FNAB in nodules larger than 3 cm was high. Therefore, we have concluded that in the event of malignant FNAB, this rate is significant; however, in the event of benign FNAB, it should not be trusted too much.
背景/目的：探讨细针穿刺活检（FNAB）在甲状腺结节中的可靠性和良恶性鉴别，尤其是在大结节中。
对 402 例甲状腺结节患者的 1466 个结节进行回顾性分析。比较术前 FNAB 和术后手术病理结果的甲状腺结节病理结果。
FNAB 与术后病理结果相符。在结节小于 3cm 时，FNAB 与术后病理结果有很好的一致性。但结节大于 3cm 时则不然。不考虑结节大小的计算概率为：敏感性 47.65%；特异性 93.98%；假阴性率 52.35%；假阳性率 6.02%。
在我们的经验中，FNAB 在结节大于 3cm 时的假阴性率较高。因此，我们得出结论，在恶性 FNAB 的情况下，这种概率是显著的；然而，在良性 FNAB 的情况下，不能过分相信。
