甲型 H1N1 流感疫苗接种医护人员与未接种医护人员的甲型 H1N1 流感 IgG 水平比较。

The comparison of pandemic HIN1 IgG levels between HIN1 influenza-vaccinated healthcare workers and unvaccinated healthcare workers.

机构信息

Department of Internal Medicine, Kırıkkale University, Turkey.

出版信息

Turk J Med Sci. 2014;44(6):1047-50. doi: 10.3906/sag-1309-10.

Abstract

BACKGROUND/AIM: To compare pandemic H1N1 (pH1N1) IgG antibody levels between healthcare workers who were vaccinated with the pH1N1 influenza vaccine and the unvaccinated healthcare workers who were selected as the control group.

MATERIALS AND METHODS

A total of 68 healthcare workers were included in this study. Of those, 53 were adults vaccinated with the H1N1 influenza vaccine and 15 were unvaccinated. Serum samples were parsed and stored at -40 °C until they were examined.

RESULTS

Of the total 53 vaccinated healthcare workers, 16 (30.1%) were positive for IgG antibodies (titer > 11), 17 (32.0%) were negative for IgG antibodies (titer < 9), and 20 (37.7%) were borderline (titer: 9-11). Of the 15 unvaccinated healthcare workers, 1 (6.6%) was positive for IgG antibodies, 11 (73.3%) were negative for IgG antibodies, and the remaining 3 (20.0%) had borderline values (P = 0.014, P < 0.05). In both groups, there was no statistically significant difference between IgG-negative, IgG-positive, and borderline subjects in terms of age or sex.

CONCLUSION

The IgG antibody level was higher in the vaccinated healthcare workers than among the unvaccinated healthcare workers.

摘要

背景/目的：比较接种甲型 H1N1（pH1N1）流感疫苗的医护人员与未接种的对照组医护人员之间的大流行性 H1N1（pH1N1） IgG 抗体水平。

材料和方法

本研究共纳入 68 名医护人员。其中 53 人为接种 H1N1 流感疫苗的成年人，15 人为未接种者。将血清样本分离并储存在-40°C，直到检查为止。

结果

在 53 名接种疫苗的医护人员中，共有 16 人（30.1％） IgG 抗体阳性（滴度> 11），17 人（32.0％） IgG 抗体阴性（滴度<9），20 人（37.7％）为边界值（滴度：9-11）。在 15 名未接种疫苗的医护人员中，有 1 人（6.6％） IgG 抗体阳性，11 人（73.3％） IgG 抗体阴性，其余 3 人（20.0％）为边界值（P = 0.014，P <0.05）。在两组中，在 IgG 阴性、IgG 阳性和边界值人群之间，年龄或性别均无统计学差异。