全球大流行期间苏格兰未接种疫苗的医护人员中甲型流感（H1N1）血清阳性率。
Prevalence of influenza A (H1N1) seropositivity in unvaccinated healthcare workers in Scotland at the height of the global pandemic.
机构信息
Public Health and Health Policy, NHS Lothian, Waverley Gate, 2-4 Waterloo Place, Edinburgh EH1 3EG, UK.
出版信息
J Environ Public Health. 2011;2011:407505. doi: 10.1155/2011/407505. Epub 2011 Oct 3.
BACKGROUND
We set out to identify the level of previous exposure to influenza A (H1N1) in unvaccinated healthcare workers (HCWs) at the peak of the pandemic outbreak in the UK, with control samples collected prior to the outbreak.
METHODS
Cross-sectional study (seroprevalence assessed before and at pandemic peak, with questionnaire data collected at peak of outbreak) in HCWs in Scotland.
RESULTS
The prevalence of seropositivity in 493 HCWs at pandemic peak was 10.3%, which was higher than the prepandemic level by 3.7 percentage points (95% CI 0.3% to 7.3%, P = 0.048). Seropositivity rates for frontline and nonfrontline HCWs were similar.
CONCLUSION
At pandemic peak, only 10.3% of HCWs were seropositive for influenza A (H1N1), so the great majority were still susceptible to infection at the introduction of the vaccination programme. Few studies have reported on seroprevalence in unvaccinated and asymptomatic participants, so our findings may have relevance to the wider population.
背景
我们旨在确定在英国大流行爆发高峰期未接种疫苗的医护人员（HCWs）中既往接触甲型 H1N1 流感的水平，并采集了大流行爆发前的对照样本。
方法
在苏格兰的 HCWs 中进行了一项横断面研究（在大流行高峰期评估血清阳性率，并在爆发高峰期收集问卷调查数据）。
结果
在大流行高峰期的 493 名 HCWs 中，血清阳性率为 10.3%，比大流行前的水平高 3.7 个百分点（95%CI0.3%至 7.3%，P=0.048）。一线和非一线 HCWs 的血清阳性率相似。
结论
在大流行高峰期，只有 10.3%的 HCWs 对甲型 H1N1 流感呈血清阳性，因此在推出疫苗接种计划时，绝大多数 HCWs 仍易感染。很少有研究报告未接种疫苗和无症状参与者的血清阳性率，因此我们的发现可能与更广泛的人群有关。
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