精液参数与出生体重有关吗？
Are semen parameters related to birth weight?
作者信息
Faure Céline, Dupont Charlotte, Chavatte-Palmer Pascale, Gautier Benoit, Levy Rachel
机构信息
Reproductive Biology Unit, Centre d'Étude et de Conservation des Oeufs et du Sperme, Jean Verdier Hospital, Assistance Publique-Hôpitaux de Paris, Bondy, France; Nutritional Epidemiology Unit, Unité de Recerche en Epidmiologie Nutritionnelle (UREN), U1125, Unités Mixtes de Recherche (UMR), U557, Institut National Scientifique d'Etudes et de Recherches Médicales, Institut National de Recherche Agronomique (INRA), Conservatoire National des Arts et Métiers (CNAM), Centre de Recherche en Nutrition Humaine Ile de France), Sorbonne Paris Cité, Paris 13 University, Bobigny, France.
Reproductive Biology Unit, Centre d'Étude et de Conservation des Oeufs et du Sperme, Jean Verdier Hospital, Assistance Publique-Hôpitaux de Paris, Bondy, France; Nutritional Epidemiology Unit, Unité de Recerche en Epidmiologie Nutritionnelle (UREN), U1125, Unités Mixtes de Recherche (UMR), U557, Institut National Scientifique d'Etudes et de Recherches Médicales, Institut National de Recherche Agronomique (INRA), Conservatoire National des Arts et Métiers (CNAM), Centre de Recherche en Nutrition Humaine Ile de France), Sorbonne Paris Cité, Paris 13 University, Bobigny, France; INRA, UMR 1198 Biologie du Développement et Reproduction, Jouy en Josas, France.
出版信息
Fertil Steril. 2015 Jan;103(1):6-10. doi: 10.1016/j.fertnstert.2014.11.027.
UNLABELLED
Several experimental models suggest a link between maternal nutrition during gestation and reproductive function in offspring, but the impact of birth weight on male fertility in adulthood in humans is poorly documented. To study whether birth weight is associated with unexplained male subfertility later in life, we evaluated the relationship between birth weight and sperm parameters in adulthood in white subfertile men, partners of couples with primary idiopathic subfertility, and fertile men recruited within the ALIFERT (Diet and Its Relationship with Couple Infertility) study. Total sperm count, progressive motility, and sperm DNA fragmentation were analyzed in sperm, and metabolic assays were performed on blood. Birth weight was associated with sperm DNA fragmentation and inversely correlated with total sperm count, underlining the importance of the in utero environment for male reproductive function.
CLINICAL TRIAL REGISTRATION NUMBER
NCT01093378.
未标注
多个实验模型表明孕期母体营养与后代生殖功能之间存在联系，但出生体重对人类成年男性生育力的影响鲜有文献记载。为研究出生体重是否与成年后不明原因的男性生育力低下有关，我们在ALIFERT（饮食及其与夫妻不育的关系）研究中招募的白人不育男性、原发性特发性不育夫妇的男性伴侣以及可育男性中，评估了出生体重与成年后精子参数之间的关系。分析了精子中的总精子数、进行性运动能力和精子DNA碎片率，并对血液进行了代谢分析。出生体重与精子DNA碎片率相关，与总精子数呈负相关，突显了子宫内环境对男性生殖功能的重要性。
临床试验注册号
NCT01093378。
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