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溴隐亭的心血管作用。

Cardiovascular actions of bromocriptine.

作者信息

Clark B J, Scholtysik G, Flückiger E

出版信息

Acta Endocrinol Suppl (Copenh). 1978;216:75-81.

PMID:25553
Abstract

Bromocriptine lowers blood pressure in animals and in man. Results obtained in experiments performed in the dog and cat suggest three possible mechanisms of action: a) relaxation of vascular smooth muscle, principally in splanchnic and renal vessels, (b) inhibition of transmitter release from noradrenergic nerve endings, (c) central inhibition of sympathetic nerve activity. The effect of bromocriptine at each putative site of action can be explained in terms of dopamine receptor stimulation.

摘要

溴隐亭可降低动物和人类的血压。在犬和猫身上进行的实验结果提示了三种可能的作用机制:a)使血管平滑肌松弛,主要是在内脏和肾血管;b)抑制去甲肾上腺素能神经末梢释放递质;c)中枢抑制交感神经活动。溴隐亭在每个假定作用部位的效应都可用多巴胺受体激动来解释。

相似文献

1
Cardiovascular actions of bromocriptine.溴隐亭的心血管作用。
Acta Endocrinol Suppl (Copenh). 1978;216:75-81.
2
Dopamine receptors and the cardiovascular system.多巴胺受体与心血管系统
Postgrad Med J. 1981;57 Suppl 1:45-54.
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Influence of dopamine and dopaminergic agonists on relaxation of isolated rabbit ileum induced by sympathetic nerve stimulation.多巴胺及多巴胺能激动剂对交感神经刺激所致离体兔回肠舒张的影响。
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Neuronal and postjunctional components in the blood pressure effects of dopamine and bromocriptine in rabbits.多巴胺和溴隐亭对家兔血压影响中的神经元及节后成分
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引用本文的文献

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Dopaminergic inhibition of metoclopramide-induced aldosterone secretion in man. Dissociation of responses to dopamine and bromocriptine.甲氧氯普胺诱导的人体醛固酮分泌的多巴胺能抑制作用。对多巴胺和溴隐亭反应的解离。
J Clin Invest. 1980 Jul;66(1):10-8. doi: 10.1172/JCI109822.
2
Adverse effects of antiparkinsonian drugs.抗帕金森病药物的不良反应。
Drugs. 1981 May;21(5):341-53. doi: 10.2165/00003495-198121050-00002.
3
Comparison of the vasodilator action of dopamine and dopamine agonists in the renal and coronary beds of the dog.多巴胺与多巴胺激动剂在犬肾床和冠状动脉床中的血管舒张作用比较。
Br J Pharmacol. 1982 Sep;77(1):23-8. doi: 10.1111/j.1476-5381.1982.tb09264.x.
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Altered dopaminergic modulation of sympathetic nervous system activity in idiopathic edema.特发性水肿中交感神经系统活动的多巴胺能调节改变
J Endocrinol Invest. 1984 Oct;7(5):461-6. doi: 10.1007/BF03348451.
5
DL-3,4-threo-DOPS in Parkinson's disease: effects on orthostatic hypotension and dizziness.帕金森病中的DL-3,4-苏式二羟基苯丝氨酸:对体位性低血压和头晕的影响
J Neural Transm. 1983;58(3-4):305-13. doi: 10.1007/BF01252816.
6
Bromocriptine in the treatment of hypertension.溴隐亭治疗高血压
Eur J Clin Pharmacol. 1986;30(2):141-4. doi: 10.1007/BF00614291.
7
Pharmacodynamic profile of CQP 201-403, a novel 8 alpha-amino-ergoline.新型8α-氨基麦角灵CQP 201-403的药效学特征
Experientia. 1988 May 15;44(5):431-6. doi: 10.1007/BF01940539.
8
Increase of rat serum prolactin by adenosine analogs and their blockade by the methylxanthine aminophylline.腺苷类似物使大鼠血清催乳素升高及其被甲基黄嘌呤氨茶碱阻断的作用
Naunyn Schmiedebergs Arch Pharmacol. 1985 Nov;331(2-3):140-5. doi: 10.1007/BF00634230.
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Interactions between domperidone and ropinirole, a novel dopamine D2-receptor agonist.多潘立酮与新型多巴胺 D2 受体激动剂罗匹尼罗之间的相互作用。
Br J Clin Pharmacol. 1991 Oct;32(4):483-8. doi: 10.1111/j.1365-2125.1991.tb03935.x.
10
Effects of metoclopramide and bromocriptine on the renin-angiotensin-aldosterone system in man. Dopaminergic control of aldosterone.甲氧氯普胺和溴隐亭对人体肾素-血管紧张素-醛固酮系统的作用。醛固酮的多巴胺能调控。
J Clin Invest. 1979 Apr;63(4):727-35. doi: 10.1172/JCI109356.