Fujino Junya, Yamasaki Nobuyuki, Miyata Jun, Sasaki Hitoshi, Matsukawa Noriko, Takemura Ariyoshi, Tei Shisei, Sugihara Genichi, Aso Toshihiko, Fukuyama Hidenao, Takahashi Hidehiko, Inoue Kazuomi, Murai Toshiya
Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kyoto Prefectural Rakunan Hospital, 2, Hirookadani, Gokasho, Uji City, Kyoto 611-0011, Japan.
J Affect Disord. 2015 Mar 15;174:397-9. doi: 10.1016/j.jad.2014.12.009. Epub 2014 Dec 13.
Cognitive behavioral therapy (CBT) is widely used to treat major depressive disorder (MDD). Although improved response prediction could facilitate the development of individualized treatment plans, few studies have investigated whether underlying brain structure is related to CBT response in MDD.
Ten MDD patients who received individual CBT were studied in this study. We investigated the relationship between the regional gray matter (GM) volume and subsequent responses to CBT using voxel-based morphometry.
The degree of improvement in depressive symptoms was positively correlated with GM volume in the caudal portion of the anterior cingulate cortex.
The sample size was small, and the effects of medication on the results could not be excluded.
Our results, although preliminary, suggest that the anterior cingulate cortex is a key structure whose volume can be used to predict responses to CBT and is thus a potential prognostic marker in MDD.
认知行为疗法（CBT）被广泛用于治疗重度抑郁症（MDD）。尽管改善反应预测有助于制定个性化治疗方案，但很少有研究调查MDD患者潜在的脑结构是否与CBT反应相关。
本研究对10名接受个体CBT的MDD患者进行了研究。我们使用基于体素的形态测量法研究了区域灰质（GM）体积与随后对CBT反应之间的关系。
抑郁症状的改善程度与前扣带回皮质尾部的GM体积呈正相关。
样本量小，且无法排除药物对结果的影响。
我们的结果虽然是初步的，但表明前扣带回皮质是一个关键结构，其体积可用于预测对CBT的反应，因此是MDD的一个潜在预后标志物。
