Buffenstein Rochelle, Nelson O Lynne, Corbit Kevin C
Barshop Institute for Aging and Longevity Studies, University of Texas Health Science Center at San Antonio, TX University of Texas Health Science Center at San Antonio, TX USA.
Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 9916, USA.
Aging (Albany NY). 2014 Nov;6(11):913-20. doi: 10.18632/aging.100704.
The pace at which science continues to advance is astonishing. From cosmology, microprocessors, structural engineering, and DNA sequencing our lives are continually affected by science-based technology. However, progress in treating human ailments, especially age-related conditions such as cancer and Alzheimer's disease, moves at a relative snail's pace. Given that the amount of investment is not disproportionately low, one has to question why our hopes for the development of efficacious drugs for such grievous illnesses have been frustratingly unrealized. Here we discuss one aspect of drug development--rodent models--and propose an alternative approach to discovery research rooted in evolutionary experimentation. Our goal is to accelerate the conversation around how we can move towards more translative preclinical work.
科学持续进步的速度令人惊讶。从宇宙学、微处理器、结构工程到DNA测序，我们的生活不断受到基于科学的技术的影响。然而，在治疗人类疾病方面，尤其是与年龄相关的病症，如癌症和阿尔茨海默病，进展却相对缓慢。鉴于投入的资金量并非不成比例地少，人们不禁要问，为什么我们开发治疗这些严重疾病的有效药物的希望一直令人沮丧地无法实现。在这里，我们讨论药物开发的一个方面——啮齿动物模型，并提出一种基于进化实验的发现研究替代方法。我们的目标是加快关于如何朝着更具转化性的临床前工作迈进的讨论。
