通过CRISPR/Cas9基因组编辑在啮齿动物中模拟人类疾病。
Modeling human disease in rodents by CRISPR/Cas9 genome editing.
作者信息
Birling Marie-Christine, Herault Yann, Pavlovic Guillaume
机构信息
CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.
出版信息
Mamm Genome. 2017 Aug;28(7-8):291-301. doi: 10.1007/s00335-017-9703-x. Epub 2017 Jul 4.
Modeling human disease has proven to be a challenge for the scientific community. For years, generating an animal model was complicated and restricted to very few species. With the rise of CRISPR/Cas9, it is now possible to generate more or less any animal model. In this review, we will show how this technology is and will change our way to obtain relevant disease animal models and how it should impact human health.
对科学界来说，模拟人类疾病已被证明是一项挑战。多年来，生成动物模型很复杂，且仅限于极少数物种。随着CRISPR/Cas9的兴起，现在或多或少可以生成任何动物模型。在这篇综述中，我们将展示这项技术是如何以及将如何改变我们获取相关疾病动物模型的方式，以及它将如何影响人类健康。
Zotero 插件