Pruthi A K, Gupta R K, Sadana J R
Department of Veterinary Pathology, College of Veterinary Sciences, Hisar, India.
J Comp Pathol. 1989 Oct;101(3):295-305. doi: 10.1016/0021-9975(89)90039-x.
The pathology of Marek's disease (MD) was studied in chickens vaccinated separately with three different vaccines, namely herpesvirus of turkeys (HVT), inactivated Marek's disease virus (IMDV) and a bivalent vaccine. The MD-specific mortality following challenge was significantly lower (2.0 per cent) in bivalent vaccinated birds than in those vaccinated with either HVT (5.9 per cent) or IMDV (13.7 per cent) alone. The occurrence, extent and severity of gross lymphomas and lymphoproliferative lesions in visceral organs was lower in the bivalent-vaccinated birds than in other groups. Atrophy and degenerative changes were seen in unvaccinated and challenged birds but not in challenged and bivalent-vaccinated birds. Mild degenerative lesions and slight RE cell hyperplasia occurred in HVT- and IMDV-inoculated and challenged birds. The low intensity and frequency of gross and histological lesions in bivalent-vaccinated birds following challenge is highly suggestive of better vaccine-induced resistance.
对分别接种三种不同疫苗（即火鸡疱疹病毒（HVT）、灭活马立克氏病病毒（IMDV）和二价疫苗）的鸡进行了马立克氏病（MD）病理学研究。攻毒后，二价疫苗接种鸡的MD特异性死亡率（2.0%）显著低于单独接种HVT（5.9%）或IMDV（13.7%）的鸡。二价疫苗接种鸡内脏器官中大体淋巴瘤和淋巴增生性病变的发生率、范围和严重程度低于其他组。未接种疫苗且攻毒的鸡出现萎缩和退行性变化，但接种二价疫苗且攻毒的鸡未出现。接种HVT和IMDV并攻毒的鸡出现轻度退行性病变和轻微的网状内皮（RE）细胞增生。攻毒后，二价疫苗接种鸡大体和组织学病变的低强度和低频率强烈提示疫苗诱导的抵抗力更强。
